Fabricating biopolymer arrays

Details Fabricating biopolymer arrays Fabricating biopolymer arrays

2005-04-26

2005-04-26

Siew, Jeffrey (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S071100, C435S091100, C435S091200, C435S287200, C536S022100, C536S023100, C536S021000, C536S024310, C536S024320, C536S024330

Reexamination Certificate

active

06884580

ABSTRACT:
A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.

REFERENCES:
patent: 3974508 (1976-08-01), Blumenthal
patent: 4184169 (1980-01-01), Taylor et al.
patent: 4314264 (1982-02-01), Bok et al.
patent: 4399446 (1983-08-01), McCann et al.
patent: 4593296 (1986-06-01), Dagna
patent: 4607261 (1986-08-01), McCann et al.
patent: 4679059 (1987-07-01), Dagna
patent: 4771295 (1988-09-01), Baker et al.
patent: 4875055 (1989-10-01), McCann et al.
patent: 4877745 (1989-10-01), Hayes et al.
patent: 4929969 (1990-05-01), Morris
patent: 4931811 (1990-06-01), Cowger et al.
patent: 5121132 (1992-06-01), Pan et al.
patent: 5300958 (1994-04-01), Burke et al.
patent: 5510817 (1996-04-01), Sohn
patent: 5539952 (1996-07-01), Hayes et al.
patent: 5563639 (1996-10-01), Cameron et al.
patent: 5658802 (1997-08-01), Hayes et al.
patent: 5681757 (1997-10-01), Hayes
patent: 5973708 (1999-10-01), Fassler et al.
patent: 6242266 (2001-06-01), Schleifer et al.
patent: 6461812 (2002-10-01), Barth et al.
patent: WO 9525116 (1995-09-01), None
patent: WO 9810858 (1998-03-01), None
patent: WO 9825944 (1998-06-01), None
patent: WO 9841531 (1998-09-01), None
Bowtell, David D.L., “Options available—from start to finish—for obtaining expression data by microarray”, Nature Genetics Supplement, vol. 21, pp. 25-32, Jan. 1999.

Affiliated with

Also associated with

Rating

Fabricating biopolymer arrays does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fabricating biopolymer arrays, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fabricating biopolymer arrays will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3438046