FabH

Details FabH FabH

1997-08-25

1999-03-23

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

435183, 4352523, 4353201, 435 691, 435 692, 435 74, 514 44, 514120, 536 232, A61K 3851, C12N 900, C12N 120, C07H 2104

Patent

active

058855726

ABSTRACT:
The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.

REFERENCES:
Heath, et al., Regulation of Fatty Acid Elongation and Initiation by Acyl-Acyl Carrier Protein in Escherichia coli*, J. Biol Chem. (1996) 271(4), 1833-1836.
Hayashi, T. et al., Inhibition of Fatty Acid Synthesis by the Antibiotic Thiolactomycin, J. Antibiotics, (1984) 37(11), 1456-1461.
Miyakawa, et al., Thiolactomycin, A New Antibiotic IV. Biological Properties and Chemotherapeutic Activity in Mice. J. Antibiotics (1982) 35(4), 411-419.
Nawata, et al., Structure of Thiolactomycin. Acta Cryst (1989) C45, 978-979.
Noto, T. et al. Thiolactomycin, A New Antibiotic III. In Vitro Antibacterial Activity. J. Antibiotics (1982) 35(4), 401-410.
Oishi, H. et al. Thiolactomycin, A New Antibiotic I. Taxonomy of the Producing Organism, Fermentation and Biological Properties. J. Antibiotics (1982) 35(4), 391-396.
D'Agnolo,G. et al. Inhibition of Fatty Acid Synthesis by the Antibiotic Cerulenin. Specific Inactivation of .beta.-Ketoacyl-Acyl Carrier Protein Synthetase. Biochim. Biophys. Acta. (1973) 326, 155-166.
Bruck F.M. et al. In-vitro evidence for feed-back regulation of .beta.-Ketoacyl-acyl carrier protein synthase III in medium-chain fatty acid biosynthesis. Planta (1996) 198, 271-278.
Jackowski, S. et al. Acetoacetyl-acyl Carrier Protein Synthase, J. Biol Chem. (1989) 264(13), 7624-7629.
Ira I., et al., Cloning, Nucleotide Sequence, and Expression of the Escherichia coli fabD Gene, Encoding Malonyl Coenzyme A-Acyl Carrier Protein Transacylase. J. Bacteriology, (1992) 174(9), 2851-2857.
Summers, et al. Malonyl-Coenzyme A:Acyl Carrier Protein Acyltransferase of Stretomyces glaucescens: A Possible Link between Fatty Acid and Polyketide Biosynthesis. Biochemistry (1995) 34, 9389-9402.
Heath, et al., J. Biol. Chem. 271(18): 11000 (1996).
Schweizer, E., Fettsauresynthasen-Funktionsstrategien eines Multienzyms. Naturwissenschaften. Aug. 1996, vol. 83, No. 8, pp. 347-358, (entire document).
Lopez-Corcuera, et al., Expression of a Mouse Brain cDNA Encoding Novel .gamma.-Amino-butyric Acid Transporter. Journal of Biological Chemistry. 05 Sep. 1992, vol. 267, No. 25, pp. 17491-17492, figure 1, nucleotides 718-735.
Wakil, et al., Fatty Acid Synthesis and its regulation. In: Annual Review of Biochemistry, Edited by E. Snell, et al. Palo Alto: Annual Reviews, Inc. 1983, vol. 52, pp. 537-579, (entire document).

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