FabH

Details FabH FabH

1997-08-25

1998-07-21

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

530350, 435 691, 4352523, 4353201, 536 232, 536 237, C12N 900, C12N 120, C12N 1500, C12P 2106

Patent

active

057834326

ABSTRACT:
The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.

REFERENCES:
Heath, et al., Regulation of Fatty Acid Elongation and Initiation by Acyl-Acyl Carrier Protein in Escherichia coli, J. Biol. Chem. (1996) 271(4), 1833-1836.
Hayashi, T. et al., Inhibition of Fatty Acid Synthesis by the Antibiotic Thiolactomycin, J. Antibiotics, (1984) 37(11), 1456-1461.
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Nawata, et al., Structure of Thiolactomycin, Acta Cryst (1989) C45, 978-979.
Noto, T. et al. Thiolactomycin A New Antibiotic III. In Vitro Antibacterial Activity. J. Antiobiotics (1982) 35(4), 401-410.
Oishi, H. et al., Thiolactomycin, A New Antibiotic J. Taxonomy of the Producing Organism Fermentation and Biological Properties, J. Antibiotics (1982) 35(4), 391-396.
D'Agnolo, G. et al. Inhibition of Fatty Acid Synthesis by the Antibiotic Cerulenin Specific Inactivation of .beta.-Ketoacyl-Acyl Carrier Protein Synthesis. Biochem. Biophys. Acta. (1973) 326, 155-166.
Bruck F.M. et al. In-vitro evidence for feed-back regulation of .beta.-Ketoacyl-acyl carrier protein synthase III in medium-chain fatty acid biosynthesis. Planta (1996) 198, 271-278.
Jackowski, S. et al. Acetoacetyl-acyl Carrier Protein Synthase. J. Biol. Chem. (1989) 264(13), 7624-7629.
Ira I., et al., Cloning, Nucleotide Sequence, and Expression of the Escherichia coli fabD Gene, Encoding Malonyl Coenzyme A-Acyl Carrier Protein Transacylase. J. Bacteriology, (1992) 174(9), 2851-2857.
Summers, et al. Malonyl-Coenzyme A:Acyl Carrier Protein Acyltransferase of Stretomyces glaucescens: A Possible Link between Fatty Acid and Polyketide Biosynthesis, Biochemistry (1995) 34, 9389-9402.

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