Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1996-11-18
1998-06-02
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435 691, 4352523, 4353201, 536 231, 536 237, 530350, C12N 900, C12N 1500, C12N 120, C07H 2104
Patent
active
057598320
ABSTRACT:
The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.
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Gentry Daniel Robert
Lonsdale John Timothy
Payne David John
Pearson Stewart Campbell
Gimmi Edward R.
King William T.
Lentz Edward T.
Saidha Tekchand
SmithKline Beecham Corporation
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