Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1986-09-08
1988-10-25
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 46, 514 49, 514 50, 536 23, 536 24, 536 26, A61K 3170, C07H 1702
Patent
active
047804521
ABSTRACT:
This invention discloses a group of compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, COOR.sup.4 (R.sup.4 is H or C.sub.1-4 alkyl) or trifluoromethyl; R.sup.2, R.sup.5 and R.sup.6 are the same or different and can be hydrogen, hydroxy, OCOR.sup.7 (wherein R.sup.7 is hydrogen, C.sub.1-4 alkyl, phenyl optionally substituted) or halo; and R.sup.3 is hydrogen, COR.sup.4, C.sub.3-6 cycloalkyl or C.sub.1-4 alkyl or alkenyl; R.sup.2 may also be a phosphate group and pharmaceutically acceptable salts thereof which have been found to have analgesic activity. In addition, these compounds have antiinflammatory, antipyretic, antihypertensive and vasodilatory activity in varying degrees. Some of these compounds also have antiprotozoal and antiviral properties.
REFERENCES:
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4322411 (1982-03-01), Vinegar et al.
Gupta et al., Indian J. of Chemistry, vol. 20B (9), pp. 817-819, 1981.
Koszalka George W.
Krenitsky Thomas A.
Rideout Janet L.
Brown Donald
Brown J. R.
Burroughs Wellcome Co.
Crane L. Eric
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