F-substituted-3-.beta.-D-ribofuranosyl-3H-imidazo[4,5-b]pyridine

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 46, 514 49, 514 50, 536 23, 536 24, 536 26, A61K 3170, C07H 1702

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047804521

ABSTRACT:
This invention discloses a group of compounds of formula (I) ##STR1## wherein R.sup.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, COOR.sup.4 (R.sup.4 is H or C.sub.1-4 alkyl) or trifluoromethyl; R.sup.2, R.sup.5 and R.sup.6 are the same or different and can be hydrogen, hydroxy, OCOR.sup.7 (wherein R.sup.7 is hydrogen, C.sub.1-4 alkyl, phenyl optionally substituted) or halo; and R.sup.3 is hydrogen, COR.sup.4, C.sub.3-6 cycloalkyl or C.sub.1-4 alkyl or alkenyl; R.sup.2 may also be a phosphate group and pharmaceutically acceptable salts thereof which have been found to have analgesic activity. In addition, these compounds have antiinflammatory, antipyretic, antihypertensive and vasodilatory activity in varying degrees. Some of these compounds also have antiprotozoal and antiviral properties.

REFERENCES:
patent: 4309419 (1982-01-01), Wolberg et al.
patent: 4322411 (1982-03-01), Vinegar et al.
Gupta et al., Indian J. of Chemistry, vol. 20B (9), pp. 817-819, 1981.

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