F.sub.0 ATP synthase subunit

Details F.sub.0 ATP synthase subunit F.sub.0 ATP synthase subunit

1998-04-24

2000-08-29

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

424 945, 4241391, 514 12, 514 44, 5303879, 536 231, C12N 988, A61K 3851

Patent

active

061107220

ABSTRACT:
The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.

REFERENCES:
Walker, JE and Collinson, IR, "The role of the stalk in the coupling mechanism of F.sub.1 F.sub.0 -ATPases" FEBS Letters 346:39-43 (1994).
Collinson, IR et al., "F.sub.0 Membrane Domain of ATP Synthase from Bovine Heart Mitochondria: Purification, Subunit Composition, and Reconstitution with F.sub.1 -ATPase" Biochemistry 33(25) :7971-7978 (GI 547185).
Lippe, G., et al., "ATP Synthase Complex from Beef Heart Mitochondria," The Journal of Biological Chemistry, 263(33) :18627-18634 (1988).
Medd, S.M., et al., "Characterization of the expressed genes for subunit c of mitochondrial ATP synthase in sheep with ceroid lipofuscinosis," Biochem. Journal, 293:65-73 (1993).

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