Eyedrops having non-Newtonian rheological properties

Details Eyedrops having non-Newtonian rheological properties Eyedrops having non-Newtonian rheological properties

1990-11-30

1992-04-21

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

514912, 424 7831, 424 7832, A61K 3178, A61K 3174

Patent

active

051066157

ABSTRACT:
Isotonic humectant eyedrops which have pronounced non-Newtonian rheological properties, simulating the rheological behavior of human tears. The eyedrops are of value in the treatment of various abnormal states of the eye such as dry eye syndrome. They can also serve as carrier for a variety of pharmaceutically active ingredients. Essential components are in combination water, an anionic polymer having a M.W. in the 500,000 to about 4,000,000 range at a concentration so that the viscosity measured at a 1 sec.sup.-1 shear rate does not exceed about 150 cp. and a low molecular weight (of 500 or less M.W.) humectant polyol at a concentration of about isotonicity or slightly above. The solution must contain less than about 1.5 mM salt calculated as sodium chloride, not including the salts of the anionic polymeric viscosity enhancer, as higher concentrations destroy the non-Newtonian rheological properties. A process for treating dry eye syndrome by application of such eyedrops.

REFERENCES:
patent: 4540568 (1985-09-01), Tragar et al.
patent: 4620979 (1986-11-01), Schachar
Survey of Opthalmology, vol. 22, No. 2, Sep.-1977, pp. 69-87, Holly et al.

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