Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1997-08-20
2000-04-25
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
54913, 424427, 424428, 424429, A61K 31195
Patent
active
060544856
ABSTRACT:
The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.
REFERENCES:
patent: 2798053 (1957-07-01), Brown
patent: 4136250 (1979-01-01), Mueller et al.
patent: 4192827 (1980-03-01), Mueller et al.
patent: 4548990 (1985-10-01), Mueller et al.
patent: 5474985 (1995-12-01), Polansky et al.
patent: 5486165 (1996-01-01), Stegmann
Alvarado et al., "Human trabecular cells II: Ultrastructural characteristics of cultured trabecular cells", Invest. Ophthalmol. Vis. Sci., vol. 23:464-478 (1982).
Apriletti J. et al., "Large Scale Purification of the Nucelar Thyroid Hormone Receptor from Rat Liver and Sequence-specific Binding of the Receptor to DNA", J. Biol. Chem. vol. 263:9409-9417 (1988).
Apriletti J. et al., Expression of the Rat .alpha.1 Thyroid Hormone Receptor Ligand Binding Domain in Escherichia Coli and the Use of a Ligand-Induced Conformation Change as a Method for Its Purification to Homegeity, Protein Expression and Purification, vol. 6:363-370 (1995).
Ashton, P. et al., "Review: Implants", J. of Occ. Pharm., vol. 10:691-701 (1994).
Hallman V.L., "Effect of Thyroid Hormones on Intraocular Pressure," Exptl. Eye Res., vol. 6:219-226 (1967).
Jorgensen, "Thyroid Hormones and Analogs", in Hormonal Proteins and Peptides, vol. 6, Thyroid Hormones (Choh Hao Li, ed.) pp. 107-204 (1978).
Lam et al., "Hydraulic Flow Conductivity of Hyaluronic Acids Solutions: Effects on Concentration and Molecular Weight," Biorheology, vol. 27:789-795 (1990).
Lavin T. N. "Mechanisms of Thyroid Hormone Action", in Endocrinology (Degroot, Ed.), 2nd Edition, W.B. Saunders, pub. (1989).
Lewis et al., "Formation of Quinol Ethers using (Diacetoxyiodo)benzene", Synthesis, vol. 1103 (1987).
Murphy, B.P. et al., "The Determination of Thyroxine by Competitive Protein-binding Analysis Employing an Anion-exchange Resin and Radiothyroxine", J. Lab and Clin. Med., vol. 66:161-167 (1965).
Oppenheimer, J.H. et al., "Stereospecific Transport of Triiodothyronine from Plasma to Cytosol and from Cytosol to Nucleus in Rat Liver, Brain, and Heart", J. Clin. Invest., vol. 75:147-154 (1985).
Polansky et al., "Trabecular Meshwork Cell Culture in Glaucoma Research: Evaluation of Biological Activity and Structural Properties of Human Trabecular Cell In Vitro", Opthalmology, vol. 91:580-595 (1984).
Polansky et al., Studies on human trabecular cells propagated in vitro, Vision Res., vol. 21:155 (1981).
Polansky et al., Human trabecular cells I: Establishment in tissue culture and growth characteristics, Invest. Opthalmol. Vis. Sci. vol. 18:1043-1049 (1979).
Ribeiro et al., "Thyroid Hormone Export Regulates Cellular Hormone Content and Response," The Journal of Biological Chemistry, vol. 271(29):17147-17151 (1996).
Samuels et al., "Depletion of L-3,5,3'-Triiodothyronine and L-Thyroxine in Euthyroid Calf Serum for Use in Cell Culture Studies of the Action of Thyroid Hormone", J. Endocrinology, vol. 105(1): 80-85 (1979).
Schwartz, H.L., et al., "Distribution and Metabolism of L- and D-Triiodothyronine (T3) in the Rat: Preferential Accumulation of L-T3 by Hepatic and Cardiac Nuclei as a Probably Explanation of the Differential Biological Potency of T3 Enantiomers", Endocrinology, vol. 113:1236 (1983).
Schwartz, H.L. et al., "Quantitation of Rat Tissue Hormone Binding Receptor Isoforms by Immunoprecipitation of Nuclear Triiodothyronine Binding Capacity", J. Biol. Chem., vol. 267(17) :11794-11799 (1992).
Shishiba et al., Effect of Thyroid Hormone Deficiency on Proteoglycan Synthesis by Human Skin Fibroblast Cultures, Connective Tissue Research, vol. 17:119-135 (1988).
Smith et al., "An ocular dynamic study supporting the hypothesis that hypothyroidism is a treatable cause of secondary open-angle glaucoma," Can. J. Ophthalmology, vol. 27(7) :341-344 (1992).
Smith et al., "An Association between Hypothyroidism and Primary Open-angle Glaucoma," Ophthalmology, vol. 100(10) :1580-1584 (1993).
Smith T.J. et al., "Regulation of Glycosaminoglycan Synthesis by Thyroid Hormone in Vitro," J. Clin. Invest., vol. 70:1066-1073 (1982).
Smith T.J., The Effect of Thyroid Hormone on Glycosaminoglycan Accumulation in Human Skin Fibroblasts, Endocrinology, vol. 108(6) :2397-2399 (1981).
Stern & Stern, "An ELISA-Like Assay for Hyalurodinase and Hyaluronidase Inhibitors", Matrix, vol. 12(5) :397-403 (1992).
Baxter John D.
Jumper Michele D.
Scanlan Thomas S.
Schwartz Daniel M.
Regents of the University of California
Witz Jean C.
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