Extrusion technique for producing unilamellar vesicles

Details Extrusion technique for producing unilamellar vesicles Extrusion technique for producing unilamellar vesicles

1989-02-13

1991-04-16

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424 11, 424450, 4284022, 436829, A61K 9133, A61K 3722

Patent

active

050080504

ABSTRACT:
A method for reducing the lamellarity of a population of liposomes is provided which comprises repeatedly passing the liposomes under pressure through a filter which has a pore size equal to or less than about 100 nm. In certain embodiments, the method is used to convert a population of previously formed multilamellar liposomes into a population of substantially unilamellar liposomes. In accordance with other aspects of the disclosure, liposomes are prepared directly from a lipid powder or pellet and buffer without the use of any solvents, detergents or other extraneous materials.

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