Extrusion process for the preparation of anhydrous stable lactos

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

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127 31, 127 42, 127 63, 536 1, C13K 500, A61K 3316

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active

042809975

ABSTRACT:
Anhydrous stable lactose is obtained by extruding crystalline .alpha.-lactose hydrate as a dry product in an extruder the jacket of which is heated to temperatures above 100.degree. C. Preferably an extruder is used in which a gradual controlled build-up of shear takes place.

REFERENCES:
patent: 2182619 (1939-12-01), Sharp
patent: 2319562 (1943-05-01), Sharp
patent: 3802914 (1974-04-01), Nezbed
patent: 4083733 (1978-04-01), Asano
Chemical Abstracts, 65:8681c (1966).

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