Extruded multi-particulates

Details Extruded multi-particulates Extruded multi-particulates

1994-11-04

1999-10-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424468, 424484, 424486, 424487, 424488, 424489, 5147723, 5147726, 514781, 514783, 514784, A61K 916, A61K 922, A61K 926, A61K 952

Patent

active

059651610

ABSTRACT:
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an optional water-insoluble binder is disclosed. The particles have a length of from about 0.1 to about 12 mm and can be of varying diameters and each unit dose provides a release of therapeutically active agents over at least about 8 hours. Methods of preparing the unit doses as well as extrusion processes and methods of treatment are also disclosed.

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