Extravascular circulation of oxygenated synthetic nutrients to t

Details Extravascular circulation of oxygenated synthetic nutrients to t Extravascular circulation of oxygenated synthetic nutrients to t

1988-04-14

1989-05-16

Swisher, Nancy A. B.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

424 9, 128632, G01N 100, G01N 3348

Patent

active

048308498

ABSTRACT:
A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the crebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

REFERENCES:
patent: 3482575 (1969-12-01), Claff et al.
patent: 3516410 (1970-06-01), Hakim
patent: 3583387 (1971-06-01), Garner
patent: 3626950 (1971-12-01), Schulte
patent: 3669094 (1972-06-01), Heyer
patent: 3669116 (1972-06-01), Heyer
patent: 3690323 (1972-09-01), Wortman et al.
patent: 3753865 (1973-08-01), Belzer
patent: 3818229 (1974-06-01), Long, Jr.
patent: 3823091 (1974-07-01), Samejima
patent: 3894541 (1975-07-01), El-Shafei
patent: 3941119 (1976-03-01), Corrales
patent: 3946731 (1976-03-01), Lichtenstein
patent: 3962439 (1976-06-01), Yokoyama et al.
patent: 3975512 (1976-08-01), Long, Jr.
patent: 3989843 (1976-11-01), Chabert et al.
patent: 4009270 (1977-02-01), Gainer, Jr.
patent: 4070460 (1978-01-01), Gainer, Jr.
patent: 4073879 (1978-02-01), Long, Jr.
patent: 4110474 (1978-08-01), Lagow et al.
patent: 4148314 (1979-04-01), Yin
patent: 4163734 (1979-04-01), Sorensen et al.
patent: 4173224 (1979-11-01), Marx et al.
patent: 4173654 (1979-11-01), Scherer
patent: 4299728 (1981-11-01), Cormier et al.
patent: 4378797 (1983-04-01), Osterholm
patent: 4393863 (1983-07-01), Osterholm
patent: 4423077 (1983-12-01), Sloviter
patent: 4443480 (1984-04-01), Clark, Jr.
patent: 4445500 (1984-05-01), Osterholm
patent: 4445514 (1984-05-01), Osterholm
patent: 4445886 (1984-05-01), Osterholm
patent: 4445887 (1984-05-01), Osterholm
patent: 4445888 (1984-05-01), Osterholm
patent: 4446154 (1984-05-01), Osterholm
patent: 4446155 (1984-05-01), Osterholm
patent: 4450841 (1984-05-01), Osterholm
patent: 4451251 (1984-05-01), Osterholm
Rodnight, R., Biochemistry Journal, vol. 57, p. 661.
Clark et al., Science, vol. 152, pp. 1755-1756 (1966).
Gollon, F. et al., Alabama Journal of Medical Science, vol. 4, p. 336 (1967).
Bose, B. et al., "Focal Cerebral Ischemia: Reduction in Size of Infarcts by Ventriculo-Subarachnoid Perfusion with Fluorocarbon Emulsion", Brain Research, 328 (1985), 223-231.
Brochure for the H-1500 Elliptical Oxygenator--Harvey Cardiopulmonary Div. of C. R. Bard, Inc.
Siegel et al., Basic Neurochemistry, 2d Little Brown Boston (1978), p. 297.
Gollon, F. et al., The Physiologist, vol. 9, p. 191 (1966).
Sloviter, H. A. et al., Nature (London), vol. 216, p. 458 (1967).
Geyer, R. P., Federation Proceedings, vol. 29, No. 5, Sep.-Oct., 1970.
Geyer, R. P., Med u Ernohn, vol. 11, p. 256 (1970).
Krone, W. et al., Biochemika et Biophysica Acta, vol. 372, pp. 55-71 (1974).
Rosenblum, W. I., "Fluorocarbon Emulsions and Cerebral Microcirculation," Federation Proceedings, vol. 34, No. 6, p. 1493 (May, 1975).
Kontos, H. A. et al., "Role of Tissue Hypoxemia in Local Regulation of Cerebral Microcirculation," American Journal of Physiology, vol. 363, pp. 582-591 (1978).
Hare et al., "Rapid and Sensitive Ion-Exchange Fluorometric Measurement of G-Aminobutyric Acid in Physiological Fluids", Anal. Biochem, vol. 101, pp. 349-355 (1980).
Navari et al., Res. Exp. Med., vol. 170, pp. 169-180 (1977).
Clark et al., Fed. Proc., vol. 34, pp. 1468-1477 (1979).
Osterholm, J. L., Pathophysiology of Spinal Cord Injury, C. C. Thomas, Springfield, Ill. (1978).
Pappenheimer, J. R. et al., "Perfusion of the Cerebral Ventricular System in Unanesthetized Goats," Am. J. Physiol., vol. 203, No. 5, pp. 763-774 (1962).
Curtis, C., "Blood and Money", Forbes, pp. 100-102, Nov. 9, 1981).
Dirks et al., "Fluorocarbon Perfusion Medium Applied to the Isolated Rat Brain", Journal of Pharmacological Methods 4:95-108 (1980).
Fischer et al., "Reassessment of Cerebral Capillary Changes in Acute Global Ischemia and Their Relationship to the `No-Reflow Phenomenon`", Stroke, vol. 8, pp. 36-39 (1977).
Carey et al., "The Effect of Severe Hypoglycemia Upon Cerebrospinal Fluid Formation, Ventricular Iodide Clearance, and Brain Electrolytes in Rabbits", J. Neurosurg., vol. 54, pp. 370-379 (1981).
Chiang et al., "Cerebral Ischemia: Vascular Changes", American Journal of Pathology, vol. 52, pp. 455-476, (1968).
Clark et al., "Can Fluorocarbon Emulsions Be Used as Artificial Blood?" Triangle, vol. 11, No. 4, pp. 115-122 (1972).
Britton et al., "Effect of Cerebral Extracellular Fluid Acidity on Total and Regional Cerebral Blood Flow", Journal of Applied Phys., vol. 47, pp. 818-826, Oct.-Dec. (1979).
Brown et al., "Fluorocarbon Sonicated as a Substitute for Erythrocytes in Rat Liver Perfusion", Surgery, vol. 71, No. 3, pp. 388-394 (Mar., 1972).
Callaghan et al., "CSF Perfusion to Treat Intraventricular Penicillin Toxicity", Arch. Neurol., vol. 38, pp. 390-391 (1981).
Astrup et al., "The Increase in Extracellular Potassium Concentration in the Ischemic Brain in Relation to the Preischemic Functional Activity and Cerebral Metabolic Rate" Brain Research, 199:161-174 (1980).
Ames et al., "Cerebral Ischemia: II. The No-Reflow Phenomenon", Am. J. Pathol., vol. 52, No. 2, pp. 437-448 (1968).
Berkenbosch et al., "Influence of the CSF Bicarbonate Concentration on the Ventilatory Response to CO.sub.2 in Relation to the Location of the Central Chemoreceptors" Respiration Physiology, 35:215-236 (1978).
Sklar, Frederick H. et al., "Recirculatory Spinal Subarachnoid Perfusions in Dogs: A Method for Determining CSF Dynamics Under Non-Steady State Conditions," Neurosurgery, vol. 1, No. 1, pp. 48-56 (1977).
Sloviter, Henry A. et al., "Erythrocyte Substitute for Perfusion of Brain," Nature, vol. 216, pp. 458-460 (Nov. 4, 1967).
Hansebout, Robert R. et al., "Oxygenated Fluorocarbon Perfusion as Treatment of Acute Spinal Cord Compression Injury in Dogs," J. Neurosurg., vol. 55, pp. 725-732 (1981).
Geyer et al., "9 Survival of Rats Totally Perfused with a Fluorocarbon-Detergent Preparation", Organ Perfusion and Preservation, pp. 85-96 (1968).
Glogar et al., "Fluorocarbons Reduce Myocardial Ischemic Damage After Coronary Occlusion", Science, vol. 211, pp. 1439-1441 (Mar., 1981).
Gould et al., "How Good are Fluorocarbon Emulsions as O.sub.2 Carriers?", Departments of Surgery, Michael Reese Hospital et al., pp. 1-3.
Fischer, E., "Impaired Perfusion Following Cerebrovascular Stasis", Arch Neurol., vol. 29, pp. 361-366 (Dec. 1973).
Fritschka et al., "Total and Regional Cerebral Blood Flow During Perfusion from the Lateral Ventricle to the Cisterna Magna in Conscious Dog: Effect of Hemorrhagic Hypotension and Retransfusion on Cerebral Blood Flow", Circulatory Shock 7:333-342 (1980).
Fritschka et al., "Increased Free Fatty Acid Turnover in CSF During Hypotension in Dogs", American J. Physiology, v. 236, pp. H802-H807, (1979).
Grote, J., "Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion", Adv. in Exp. Med. Biol., vol. 75, pp. 313-324, (1975).
Heisey et al., "Bulk Flow and Diffusion in the Cerebrospinal Fluid System of the Goat", American J. of Physic., vol. 203, pp. 775-781 (1962).
Hossmann et al., "Cation Activities in Reversible Ischemia of the Cat Brain", Stroke, vol. 8, pp. 77-81, (1977)
Hossmann et al., "Resuscitation in the Monkey Brain After 1 H Complete Ischemia, 1. Physiological and Morphological Observations," Brain Research, 81:59-74 (1974).
Hossmann et al., "Reversibility of Ischemic Brain Damage", Arch. Neurol., vol. 29, pp. 375-384 (Dec. 1973).
Javid et al., "Hypothermic Ventricular Perfusion--Evaluation of Use in Cerebrovascular Occlusion", New York State Journal of Medicine, pp. 248-251 (Jan. 15, 1967).
Kleihues et al., "Purine Nucletide Metabolism in the Cat Brain After One Hour of Complete Ischemia", Journal of Neurochemistry, vol. 23,

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