Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-04-08
1995-10-03
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 424426, A61K 912
Patent
active
054550394
ABSTRACT:
A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
REFERENCES:
patent: 3797485 (1974-03-01), Urguhart
patent: 3993071 (1976-11-01), Higuchi et al.
patent: 4391797 (1983-07-01), Folkman et al.
patent: 4495174 (1985-01-01), Allock et al.
patent: 4808402 (1989-02-01), Leibovich
patent: 4898732 (1990-02-01), Fernandez
Mayberg et al., 1988, Surgical Forum 39:496-499.
Okada et al., 1988, 19:1470-1476.
Okada et al., 1989 Neurosurgery 25:892-898.
Lotran et al., 1989 Robbins Pathologic Basis of Disease, pp. 73-74, 253-254, 553-557, 562-565.
Mayberg et al. 1981, Science 213:228-230.
Moskowitz et al., 1981, Brain Research 212:460-465.
Anti coagulant, anti thrombotic and thrombolytic drugs O'Reilly in The Phamacologic Basics of Therapeutics, 7th ed. Gilman et al eds. McMillan Pub. Co. 1985, p. 1338.
Inhibitors of angiotensin-converting enzyme prevent myointimal proliferate powell et al. Science 245, 186 (1989).
Structural Determinants of the Capacity of Heparin to Inhibit the Proliferate--Costellot et al. J. Cell Physiol. 120, 315 (1984).
Considerazioni sull'uso dell-- Molino et al. Min. Cardioang., 21, 553 (1973).
Powell et al. Science 245, 186 (1989).
Costellot et al J. Cell Physiol. 120, 315 (1984).
Molino et al. Min. Cardioang. 21, 553 (1973).
Okada et al, Neurosurgery, 25, 892, 1989.
Okada et al, Stroke 19, 1470, 1988.
McBride, et al., "Restenosis After Successful Coronary Angioplasty: Pathophysiology and Prevention," The New England Journal of Medicine, vol. 318, No. 26: 1734-1737 (1988).
Simpfendorfer, "Acute Coronary Occlusion After Percutaneous Transluminal Coronary Angioplasty," Cleveland Clinic Journal of Medicine, vol. 55, No. 5: 429-432 (1988).
Fishman, et al., "Endothelial Regeneration in the Rat Cartoid Artery and the Significance of Endothelial Denudation in the Pathogenesis of Myointimal Thickening," Laboratory Investigation, vol. 32, No. 3: 339-351 (1975).
Austin, et al. "Intimal Proliferation of Smooth Muscle Cells as an Explanation for Recurrent Coronary Artery Stenosis After Percutaneous Transluminal Coronary Angioplasty," J. Am. Coll. Cardiol., vol. 6, No. 2: 369-375 (1985).
Diaz-Flores, et al., "Relation Between Arterial Intimal Thickening and the Vasa-Vasorum," Virchows Arch [Pathol Anat], vol. 406: 165-177 (1985).
Steele, et al., "Balloon Angioplasty: Natural History of the Pathophysiological Response to Injury in a Pig Model," Circulation Research, vol. 57, No. 1: 105-112 (1985).
Clowes, et al., "Suppression by Heparin of Smooth Muscle Cell Proliferation in Injured Arteries," Nature, vol. 265:625-626 (1977).
Castellot, Jr., "Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells," Journal of Cellular Physiology, vol. 120:315-320 (1984).
Castellot, Jr., et al., "Structural Determinants of the Capacity of Heparin to Inhibit the Proliferation of Vascular Smooth Muscle Cells. II".
"Evidence for a Pentasaccharide Sequence That Contains a 3-O-Sulfate Group," The Journal of Cell Biology, vol. 102:1979-1984 (1986).
Jaques, "Drug Prophylaxis in Atherosclerosis," Artery, vol. 14, No. 4:209-215 (1987).
Bick, et al., "Clinical Use of Intrapulmonary Heparin," Seminars in Thrombosis and Hemostasis, vol. 11, No. 2:213-217 (1985).
Mahadoo, et al., "Cellular Control of Heparin in Blood," Medical Hypotheses 5:825-841 (1979).
Mahadoo, et al., "Endothelial Sequestration of Heparin Administered by the Intrapulmonary Route," Artery, vol. 7, No. 5:438-477 (1980).
Larsen, et al., "Oral Heparin Results in the Appearance of Heparin Fragments in the Plasma of Rats," Proc. Natl. Acad. Sci. USA, vol. 83: 2964-2968 (1986).
Bentley, et al., "An Objective Study of Alternative Methods of Heparin Administration," Thrombosis Research, vol. 18:177-187 (1980).
Dawes, et al., "Absorption of Heparin, LMW Heparin and SP54 After Subcutaneous Injection, Assessed by Competitive Binding Assay," Thrombosis Research, vol. 44:683-693 (1986).
Habib, et al., "Preservation of Endothelium-Dependent Vascular Relaxation in Cholesterol-Fed Rabbit by Treatment with the Calcium Blocker PN 200110," Circulation Research, vol. 58, No. 2:305-309 (1986).
Whitworth, et al., "Effect of Nifedipine on Recurrent Stenosis After Percutaneous Transluminal Coronary Angioplasty," J. Am. Coll. Cardiol., vol. 8:1271-1276 (1986).
Powell et al., "Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury," Science, vol. 245:186-188 (1989).
Gordon et al., "Clinical Cardiology: Restenosis After PTCA," Circ. Supp. Abstracts of the 60th Scientific Sessions, vol. 76, No. 4: IV-213 (1987).
Langer et al., "Controlled Release and Magnetically Modulated Release Systems for Macromolecules," Methods in Enyzmology, 112:399-423 (1985).
Brown, et al., "In Vivo and In Vitro Release of Macromolecules from Polymeric Drug Delivery Systems," Journal of Pharmaceutical Sciences, vol. 72, No.10:1181-1185 (1983).
Sparer, et al., "Controlled Release From Erodible Poly(ortho Ester) Drug Delivery Systems," Journal of Controlled Release, vol. 1:23-32 (1984).
Lawter, et al., "Drug Release From Poly(Glycolide-CO-DL-Lactide) Microcapsules," Proceed. Intern. Symp. Control Rel. Bioact. Mater., vol. 14:99-100 (1987).
Neenan, et al., "Synthesis of a Heparinized Poly(Organophosphazene)," Biomaterials, vol. 3:78-80 (1982).
Grolleman, et al., "Studies on a Bioerodible Drug Carrier System Based on Polyohosphazene Part I. Synthesis," Journal of Controlled Release, vol. 3:143-154 (1986).
Ellis et al., "Results of a Randomized Trial of Heparin and Aspirin vs. Aspirin Alone for Prevention of Accute Closure and Restenosis After Angioplasty," Circ. Supp. Abstracts of the 60th Scientific Sessions, vol. 76, No. 4:IV-213 (1987).
Langer et al., "Controlled Release and Magnetically Modulated Systems for Macromolecular Drugs," Annals New York Academy of Sciences, 446:1-13 (198?).
Stemerman et al., "Experimental Arteriosclerosis," The J. of Experimental Medicine, 136:769-789 (1972).
Guyton et al., "Smooth Muscle Cell Proliferation in the Occluded Rat Carotid Artery," American J. of Path., 94:585-596 (1979).
Castellot, Jr. et al., "Cultured Endothelial Cells Produce a Heparinlike Inhibitor of Smooth Muscle Cell Growth," J. of Cell Bio., 90:372-379 (1981).
Molino et al., "Considerazioni sull'uso dell'Eparina long-term nei cardiovasculopatici," Min. Cardioang., 21:553-557 (1973).
O'Reilly, "Anticoagulant, Antithrombotic, and Thrombolytic Drugs," The Pharmacologic Basics of Therapeutics, 7th ed., Gilman et al., eds., Macmillan Publishing Co. (1985).
Mahadoo, "Evidence for a Cellular Pool for Exogenous Heparin" International Symposium on Heparin, Saskatoon, Sask., (1977).
Jaques et al., "Pharmacodynamics and Clinical Effectiveness of Heparin" Seminars in Thrombosis and Hemostasis, 4:298-325 (1978).
Kakkar, "Low Dose Heparin in the Prevention of Venous Thromboembolism," Thrombos. Diathes. Haemorrh., 33:87-96 (1974).
Gallus, "Prevention of Venous Thromboembolism," Seminars in Thrombosis and Hemostatis, 2:232-290 (1976).
Adams David H.
Edelman Elazer R.
Karnovsky Morris J.
Kishore Gollamudi S.
President and Fellows of Harvard College
LandOfFree
Extraluminal regulation of the growth and repair of tubular stru does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Extraluminal regulation of the growth and repair of tubular stru, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Extraluminal regulation of the growth and repair of tubular stru will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1076099