Extracts of embryonic organs, process for their preparation and

Details Extracts of embryonic organs, process for their preparation and Extracts of embryonic organs, process for their preparation and

1987-09-10

1990-03-13

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424103, 424106, 424104, 424105, 514859, 514878, A61K 3554, A61K 3523, A61K 3534, A61K 35407

Patent

active

049082060

ABSTRACT:
From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulgaris. The corresponding extracts are used as active ingredients of corresponding pharmaceutical preparations.
The new pharmaceutically active extract is prepared according to a process in which polar substances having a molecular weight below 5000 are isolated from the embryonic mammalian organs avoiding any degradation of substances having a higher molecular weight. The finely divided embryonic mammalian organs are extracted with a mixture of water and a water soluble organic solvent which contains nor more than 30 vol.-% of water at an about neutral pH value for stirring and refluxing. The resulting solution is then submitted to a predetermined sequence of further drying steps, heating steps and cooling steps, and finally to a filtration with an ultramembrane filter in order to remove any substances having a molecular weight of about 5000. The extract is then finally concentrated under vacuum to yield a liquid concentrate or a dry residue.

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