Extractive purification of lipopeptide antibiotics

Details Extractive purification of lipopeptide antibiotics Extractive purification of lipopeptide antibiotics

2006-11-21

2006-11-21

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C530S344000

Reexamination Certificate

active

07138487

ABSTRACT:
The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics, such as those having a cyclic peptide or cyclic depsipeptide core, in high yield and purity. In particular, there is provided a method of extracting a variety of acidic lipopeptide antibiotics, directly or indirectly, into water immiscible organic solvents by using a divalent cation chelation procedure.

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