Extraction of interferon from bacteria

Details Extraction of interferon from bacteria Extraction of interferon from bacteria

1980-12-29

1982-02-16

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424 87, A61K 4502

Patent

active

043158528

ABSTRACT:
A method of extracting leucocyte interferon from interferon-expressing bacterial cells comprising acidifying a suspension of interferon-containing bacterial cells, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, separating the interferon containing liquid from the suspended cells, and extracting the interferon from said liquid.

REFERENCES:
patent: 3256152 (1966-06-01), Lampson
patent: 3265581 (1966-09-01), Fantes et al.
patent: 3414651 (1968-12-01), Fantes
patent: 3699222 (1972-10-01), Isaacs et al.
patent: 4266024 (1981-05-01), Swetly et al.
Nature, vol. 287, 193-197, (1980), Derynck et al.
Nature, vol. 284, 316-320, (1980), Nagata et al.
Science, vol. 209, 1343-1347, Streuli et al.

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