Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-05-17
1990-09-18
Draper, Garnette
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530412, 530418, 530419, 530420, 530422, 530423, 530424, 530427, 530825, 435 695, 435 6952, 435 711, C07K 312
Patent
active
049580078
ABSTRACT:
A method is provided for extracting human interleukin-4 (IL-4) from IL-4 expressing bacterial cells. The method comprises treating the bacterial cells with a deactivating agent, disrupting the cell membrane and recovering the IL-4.
REFERENCES:
patent: 4364863 (1982-12-01), Leibowitz
patent: 4405601 (1983-09-01), McEntire et al.
patent: 4675387 (1987-06-01), Karant
Marston, Biochem. J., 240, 1986, pp. 1-12.
Menge et al., Develop. Biol. Std., 66, 1987, pp. 391-401.
European Journal of Biochemistry, vol. 173, No. 1, Apr. 1988, pp. 109-114.
Alroy Yair
Leibowitz Paul
Draper Garnette
Maitner John J.
Rosen Gerald S.
Schering-Plough Corp.
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