Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1987-05-11
1990-03-27
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 530412, 530418, 530419, 530422, 530427, 530825, 435 695, C07K 312
Patent
active
049122002
ABSTRACT:
A method of extracting granulocyte macrophage colony stimulating factor (GM-CSF) from GM-CSF-expressing bacterial cells comprising treating a suspension of GM-CSF-containing bacterial cells with an acid and an enhancing agent, removing substantially all of the suspension liquid from the cells, preparing a second suspension of the acidified cells, neutralizing said second suspension, and separating the GM-CSF containing liquid from the suspended cells.
REFERENCES:
patent: 4364863 (1986-12-01), Leibowitz et al.
patent: 4675387 (1987-06-01), Kerant
patent: 4801686 (1989-01-01), Kronheim
De Lamarter et al., EMBo, 4(10), 1985, pp. 2575-2581.
Clark et al., Science 236, 1987, pp. 1229-1237.
Cantrell et al., PNAS 82, 1985, pp. 6250-6254.
Alroy Yair
Leibowitz Paul
Draper Garnette D.
Dulak Norman C.
Miller Stephen I.
Nelson James R.
Schering Corporation
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