Extraction of alkaloids of Catharanthus roseus tissue

Details Extraction of alkaloids of Catharanthus roseus tissue Extraction of alkaloids of Catharanthus roseus tissue

1987-05-01

1989-05-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D51904

Patent

active

048311332

ABSTRACT:
Alkaloids present in Catharanthus roseus tissue are selectively concentrated by aqueous extraction of ground tissue followed by extraction with organic solvent e.g. ethyl acetate. The resultant concentrate is rich in catharanthine, vindoline and 3',4'-anhydrovinblastine (AVLB). Yield of AVLB is enhanced by addition to the aqueous extraction medium of acid, salt, or hydrogen peroxide and can be further enhanced through the addition of sodium borohydride.

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Endo et al., Chemical Abstracts, vol. 108(11):93051d, (1987).
Endo et al., Chemical Abstracts, vol. 108(23):201668w, (1987).

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