Image analysis – Applications – Biomedical applications
Reexamination Certificate
2005-10-18
2005-10-18
Johns, Andrew W. (Department: 2621)
Image analysis
Applications
Biomedical applications
Reexamination Certificate
active
06956961
ABSTRACT:
Methods and apparatus are provided for the analysis of images of cells and extraction biologically-significant shape-related features from the cell images. The extracted features may be correlated with particular conditions induced by biologically-active agents with which cells have been treated, thereby enabling the automated analysis of cells based on cell shape parameters. In particular, the invention provides methods for segmentation of cells in an image using a combination of a reference component image data and cell shape-indicative marker image data in a watershed technique. Further, the invention provides a skeletonization and skeleton analysis technique for extracting biologically-relevant features from cell shapes.
REFERENCES:
patent: 4818710 (1989-04-01), Sutherland et al.
patent: 4922092 (1990-05-01), Rushbrooke et al.
patent: 4959301 (1990-09-01), Weaver et al.
patent: 4965725 (1990-10-01), Rutenberg
patent: 5016283 (1991-05-01), Bacus et al.
patent: 5162990 (1992-11-01), Odeyale et al.
patent: 5163095 (1992-11-01), Kosaka
patent: RE34214 (1993-04-01), Carlsson et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5287272 (1994-02-01), Rubbenberg et al.
patent: 5326691 (1994-07-01), Hozier
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5526258 (1996-06-01), Bacus
patent: 5548661 (1996-08-01), Price et al.
patent: 5655028 (1997-08-01), Soll
patent: 5710022 (1998-01-01), Zhu et al.
patent: 5733721 (1998-03-01), Hemstreet, III et al.
patent: 5741648 (1998-04-01), Hemstreet et al.
patent: 5768412 (1998-06-01), Mitsuyama et al.
patent: 5776748 (1998-07-01), Singhvi et al.
patent: 5777888 (1998-07-01), Rine et al.
patent: 5790692 (1998-08-01), Price et al.
patent: 5790710 (1998-08-01), Price et al.
patent: 5804436 (1998-09-01), Okun et al.
patent: 5856665 (1999-01-01), Price et al.
patent: 5893095 (1999-04-01), Jain et al.
patent: 5919646 (1999-07-01), Okun et al.
patent: 5932872 (1999-08-01), Price
patent: 5962250 (1999-10-01), Gavin et al.
patent: 5976825 (1999-11-01), Hochman
patent: 5985549 (1999-11-01), Singer et al.
patent: 5989835 (1999-11-01), Dunlay et al.
patent: 5991028 (1999-11-01), Cabib et al.
patent: 5995143 (1999-11-01), Price et al.
patent: 6007996 (1999-12-01), McNamara et al.
patent: 6008010 (1999-12-01), Greenberger et al.
patent: 6078681 (2000-06-01), Silver
patent: 6083763 (2000-07-01), Balch
patent: 6103479 (2000-08-01), Taylor
patent: 6146830 (2000-11-01), Friend et al.
patent: 6169816 (2001-01-01), Ravkin
patent: 6222093 (2001-04-01), Marton et al.
patent: 6345115 (2002-02-01), Ramm et al.
patent: 6615141 (2003-09-01), Sabry et al.
patent: 6658143 (2003-12-01), Hansen et al.
patent: 2002/0141631 (2002-10-01), Vaisberg et al.
patent: 2002/0154798 (2002-10-01), Cong et al.
patent: 0468705 (1992-01-01), None
patent: 0 317 139 (1995-02-01), None
patent: 0902394 (1999-03-01), None
patent: WO 87/02802 (1987-05-01), None
patent: WO 93/21511 (1993-10-01), None
patent: WO 94/11841 (1994-05-01), None
patent: WO 95/10036 (1995-04-01), None
patent: WO 95/22749 (1995-08-01), None
patent: WO 96/01438 (1996-01-01), None
patent: WO 96/09605 (1996-03-01), None
patent: WO 97/11094 (1997-03-01), None
patent: WO 97/20198 (1997-06-01), None
patent: WO 97/40055 (1997-10-01), None
patent: WO 97/43732 (1997-11-01), None
patent: WO 97/45730 (1997-12-01), None
patent: WO 98/05959 (1998-02-01), None
patent: WO 98/35256 (1998-08-01), None
patent: WO 98/38490 (1998-09-01), None
patent: WO 98/44333 (1998-10-01), None
patent: WO 98/45704 (1998-10-01), None
patent: WO 98/52018 (1998-11-01), None
patent: WO 99/05323 (1999-02-01), None
patent: WO 99/08091 (1999-02-01), None
patent: WO 99/17116 (1999-04-01), None
patent: WO 99/39184 (1999-08-01), None
patent: WO 99/44062 (1999-09-01), None
patent: WO 99/54494 (1999-10-01), None
patent: WO 99/67739 (1999-12-01), None
patent: WO 00/03246 (2000-01-01), None
patent: WO 00/06774 (2000-02-01), None
patent: WO 00/17624 (2000-03-01), None
patent: WO 00/17643 (2000-03-01), None
patent: WO 00/17808 (2000-03-01), None
patent: WO 00/26408 (2000-05-01), None
patent: WO 00/29984 (2000-05-01), None
patent: WO 00/31534 (2000-06-01), None
patent: WO 00/33250 (2000-06-01), None
patent: WO 00/43820 (2000-07-01), None
patent: WO 00/49540 (2000-08-01), None
patent: WO 00/50872 (2000-08-01), None
patent: WO 00/60356 (2000-10-01), None
patent: WO 00/65472 (2000-11-01), None
patent: WO 00/70528 (2000-11-01), None
patent: WO0135072 (2001-05-01), None
Russ, J.C., “The Image Processing Handbook.” Second Edition. Boca Raton: CRC Press. 1995. pp. 469-474 and 457-461.
Lu et al, “Hierarchical Shape Recognition Using Polygon Approximation and Dynamic Alignment”; IEEE Paper CH2561-9, vol. 2, pp. 976-979, Apr. 1988.
Hartwell et al., “Integrating Genetic Approaches into the Discovery of Anticancer Drugs”. Science, vol. 278, Nov. 7, 1997. XP002916842.
Ng et al., “Evaluating Multi-Dimensional Indexing Structures for Images Transformed by Principal Component Analysis”. Dept. of Computer Science, University of British Colombia, Vancouver, B.C. V6T 1Z4, Canada. XP000642562.
Boland et al. “Automated Recognition of Patterns Characteristics of Subcellular Structures in Fluorescence Microscopy Images”. Cytometry 33:366-375 (1998).
Rubas, et al., “An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro,” Pharmaceutical Research, vol. 13, No. 1, (1996) pp 23-27.
Uria JA, et al., “Regulation of Collagenase-3 Expression in Human Breast Carcinomas in Mediated by Stromal-Epithelial Cell Interactions”, Cancer Res Nov. 1, 1997;57 (21):4882-8, Abstract.
Wang et al., “Immunolocalization of 6 in CHO cells with anti-His antibodies”, Dec. 1999.
Cormack, Brendan P. et al., “FACS-optimized mutants of the green fluorescent protein (GFP)”, 1996,Gene,vol. 173, pp. 33-38.
Craig, Elizabeth and Gross, Carol, “Is hsp70 the cellular thermometer?”, 1991,TIBS,pp. 135-140.
Cubitt, Andrew B. et al., “Understanding, improving and using green flourescent proteins”, 1995,TIBS,vol. 20, pp. 448-455.
Dobson, Stephen P., “Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualized using green fluorescent protein”, 1996,FEBS Letters,vol. 393, pp. 179-184.
Georget, V., et al., “Trafficking of the androgen receptor in living cells with fused green fluorescent protein—androgen receptor”, 1997,Molecular and Cellular Endorcrinology,vol. 129, pp. 17-26.
Lippincottt-Schwartz, Jennifer and Smith, Carolyn L., “Insights into secretory and endocytic membrane traffic using green fluorescent protein chimeras”, 1997,Current Opinion in Neurobiology,vol. 7, pp. 631-639.
Misteli, Tom and Spector, David L., “Applications of the green fluorescent protein in cell biology and biotechnology”, 1997,Nature Biotechnology,vol. 15, pp. 961-964.
Palm, Gottfried J. et al., “The structural basis for spectral variations in green fluorescent protein”, 1997,Nature Structural Biology,vol. 4, No. 5, pp. 361-365.
Sakai, Kenji et al., “Purification and characterization of N-acyl-D-glutamate deacylase fromAlcaligenes xylosoxydanssubsp.xylosoxydansA-6”, 1991,FEBS Letters,vol. 289, No. 1, pp. 44-46.
Shulga, Nataliya et al., “In Vivo Nuclear Transport Kinetics inSaccharamyces cerevisiae: A Role for Heat Shock Protein 70 during Targeting and Translocation”, 1996,The Journal of Cell Biology,vol. 135, No. 2, pp. 329-339.
Tarasova, Nadya I. et al., “Visualization of G Protein-coupled Receptor Trafficking with the Aid of the Green Fluorescent Protein”, 1997,The Journal of Biological Chemistry,vol. 272, No. 23, Issue of Jun. 6, pp. 14817-14824.
Welsh, Stephen and Kay, Steve A., “Reporter gene expression for monitoring gene transfer”, 1997,Current Opinion in Biotechnology,vol. 8, pp. 617-622.
Mattheakis et al., PCT Search Report for Int'l Application No. PCT/US2004/022970, Int'l Filing
Cong Ge
Vaisberg Eugeni A.
Beyer Weaver & Thomas LLP.
Cytokinetics Inc.
Johns Andrew W.
Nakhjavan Shervin
LandOfFree
Extracting shape information contained in cell images does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Extracting shape information contained in cell images, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Extracting shape information contained in cell images will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3473715