Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hapten – hapten-carrier complex – or...
Patent
1995-07-24
1997-08-26
Rollins, John W.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hapten, hapten-carrier complex, or...
514821, A61K 3578
Patent
active
056608314
DESCRIPTION:
BRIEF SUMMARY
The invention relates to an extract of flowers of Salvia officinalis (sage) and a method of producing same. Furthermore, the invention relates to a medicament having a content of extract from flowers of Salvia officinalis and the use thereof in combating circulatory disorders and high blood pressure as well as in improving the healing of wounds.
High blood pressure and related cardiovascular diseases, which are not seldomly fatal, represent one of the major problems in medicine. Circulatory disorders are also often associated with serious complications. The problem of inadequate healing of wounds exists particularly with elderly people, so that wounds fail to heal in many cases even after a lengthy period.
Although intensive efforts have been made to develop synthetic drugs or natural remedies which are effective in the case of the aforementioned indications, there is ultimately still a continuous need for new medicaments, last but not least due to the side-effects which occur repeatedly.
In addition, the developed preparations are as a rule applicable only for one of the stated indications. In particular, effective means have yet to become known which are shown to be effective both in promoting circulation and in reducing blood pressure.
The use of plant extracts as natural remedies is known from ancient times. However, the extracts obtained from various types of plants, various parts thereof or under various conditions by extraction often differ basically in their effect.
From the sage plant the use of aqueous solutions having constituents from the leaves is known to counteract excessive perspiration, catarrhs and as medications for flushing and gargling. Such solutions are obtained e.g. by treating the sage leaves with hot water. Conventional methods of obtaining sage extracts include, apart from the actual extraction stage, e.g. including the use of alcohol, a stage of distilling off the extraction vehicle at temperatures above 100.degree. C., many constituents being thermally damaged or changed thereby.
One object of the invention is to provide a method by which a novel extract having valuable constituents can be obtained from the sage plant (Salvia officinalis) whilst in particular avoiding thermal decomposition of the constituents to a major extent where possible.
The gist of the invention consists of obtaining valuable extracts from flowers of sage by implementing extraction as gentle as possible so that the valuable constituents of the flowers enter the extract practically unchanged.
The subject matter of the invention is a method of producing an extract of Salvia officinalis characterized by the flowers of this plant being extracted. The extraction is done preferably at a temperature below 50.degree. C. Furthermore, the invention relates to an extract of the flowers of Salvia officinalis obtained by the method according to the invention.
In addition, the invention has as subject matter a medicament which is characterized by a content of the extract from flowers of Salvia officinalis.
The extract obtained according to the invention is suitable for use in combating circulatory disorders and high blood pressure as well as disorders in the healing of wounds.
Extracting the flowers of Salvia officinalis can be done with the aid of any means of extraction such as water, organic solvents or supercritical CO.sub.2. One example of an organic solvent is ethanol. As already mentioned, the temperature during extraction and any subsequent stage required for removing the extractant at least in part, e.g. by distillation, should be 50.degree. C. or lower and preferably 40.degree. C. and lower to prevent thermal impairment of the constituents of the flowers. This means that in distillative separation the pressure must be reduced to the extent that the stated upper temperature limit can be maintained.
According to the invention the use of supercritical CO.sub.2 for the extraction of sage flowers is particularly preferred since it can be carried out at low temperatures and thus particularly gently.
The extraction
REFERENCES:
patent: 4942033 (1990-07-01), Aubert et al.
Hagers Handbuch Der Pharmazeutischen Praxis; Complete Fourth Edition; P.H. List and L. Horhammer; Springer-Verlag 1979.
"Chemieprodukte, Haushalt, Gewerbe, Industrie"; Seifen-Ole-Fette-Wachse; 116. Jg,; No. 16; 16 Oct. 1990.
Technologie Pflanzlicher Arzneizubereitungen; Prof. Dr. Dr. h. c. P. H. List and Prof. Dr. Peter C. Schmidt; 1984.
Chemical Abstract; vol. 103, 1985; p. 404; 103: 193127y.
Chemical Abstract; vol. 86, 1077; p. 250; 86: 117603r.
17-Food, Feed Chem.; vol. 114, 1991; p. 591; 114: 80195c.
Heilmittebetrieb Isernhagen GmbH
Rollins John W.
LandOfFree
Extract from flowers of Salvia officinalis, process of its prepa does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Extract from flowers of Salvia officinalis, process of its prepa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Extract from flowers of Salvia officinalis, process of its prepa will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1986398