Liquid purification or separation – Processes – Ion exchange or selective sorption
Patent
1987-04-30
1989-09-05
Jones, W. Gary
Liquid purification or separation
Processes
Ion exchange or selective sorption
210196, 210280, 210289, 210291, 2105021, 210679, 210805, 210807, B01D 1502
Patent
active
048636118
ABSTRACT:
An apparatus for removing material from a biological solution consisting of a reactor chamber having an inlet and an outlet, a bioactive compound immobilized on particular supports within the reactor, means for retaining the particular supports within the reactor, means for recirculating the solution and the supports at a high flow rate within the reactor, and means for agitating or dispersing the recirculating solution-support mixture throughout the reactor chamber so as to prevent packing of the supports while not subjecting the solution to excessive or damaging forces.
In the given example, an apparatus for the extracorporeal removal of heparin from blood is provided. Heparinase is immobilized on cross-linked agarose beads recirculated at a high flow rate through the reactor. Agitation of the blood-bead mixture sufficient to prevent packing of the beads within the reactor chamber is provided by means of a series of openings in the recirculation tube dispersing the mixture throughout the chamber.
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Bernstein Howard
Langer Robert S.
Wheatley Margaret A.
Jones W. Gary
Massachusetts Institute of Technology
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