Extracorporeal circulation apparatus and method

Details Extracorporeal circulation apparatus and method Extracorporeal circulation apparatus and method

1996-03-04

1998-03-10

Weiss, John G.

Surgery

Blood drawn and replaced or treated and returned to body

604 23, A61M 3700

Patent

active

057254923

ABSTRACT:
Patient blood in an extracorporeal flow circuit (such as a cardiopulmonary bypass machine) is contacted with one or more nitric oxide feeds at least one of which is upstream of the circuit pump, to provide a concentration of nitric oxide in the blood effective to inhibit activation of blood platelets and reduce whole body inflammation of the patient as a result of a procedure using the extracorporeal circulation.

REFERENCES:
Bernabel A., et al., "Iloprast and Echistatin protect platelets during simulated extracorporeal circulation," ANN. THORAC. SURG. 1995; 59:149-153.
J.H. Gorman and L. Henry Edmunds, Jr., "Blood Anesthesia for Cardiopulmonary bypass," J. CARD. SURG. 1995, 10, 270-279.
Hammon J.W. et al., "Augmentation of Microvascular Nitric Oxide Improves Myocardial Performance Following Global Ischemia," J. CARD. SURG., 1995, 10 (Supp), 423-427.
Sly K., et al., "Inhibition of Surface-Induced Platelet Activation By Nitric Oxide," ASAIO Journal 1995;41:M394-M398.
Yao S., et al., "Endogenous And Exogenous Nitric Oxide Protect Intracoronary Thrombosis And Reocclusion After Thrombolysis", CIRCULATION, 92:1005-1010, 1995.
L. Henry Edmonds, "Breaking the Blood-Biomaterial Barrier," presented at the Cardiovascular Science and Technology Conference, Washington, D.C., Dec. 9, 1994.
Blackstone E.H. et al "the Damaging Effects of Cardiopulmonary Bypass," in Wu K.K., roxy E.C. (eds), PROSTAGLANDINS IN CLINICAL MEDICINE:CARDIOVASCULAR AND THROMBOTIC DISORDERS, Chicago, Yearbood Medical Publishers, 1982, pp. 355-369.

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