Liquid purification or separation – With means to add treating material – With distinct reactor tank – trough or compartment
Patent
1986-11-24
1989-01-24
Fisher, Richard V.
Liquid purification or separation
With means to add treating material
With distinct reactor tank, trough or compartment
2102572, 210259, 210263, 210295, 21032172, 2105021, 502404, 502401, 604 5, 424101, B01D 3602
Patent
active
048000167
ABSTRACT:
Heparin in an extracorporeal blood flow circuit is removed from the blood flow with the use of a filter which contains immobilized protamine on a blood-compatible support. In medical procedures where blood is processed in an extracorporeal device, such as an artificial kidney, or a heart-lung machine, the blood is heparinized to prevent clotting thereof in the channels of the extracorporeal device, and the formation of thrombi. In accordance with the invention, the processed, heparinized blood is conducted to a filter arrangement wherein protamine is held immobilized on a support formed of a blood-compatible material. Such an arrangement actually removes heparin from the blood rather than merely negates the anticoagulation effects of the heparin, as is the case in conventional protamine infusion therapy. In the present invention, the extracorporeal blood which is returned to the patient is substantially free of both heparin and protamine. Various chemical mechanisms are presented for activating a polymeric support material so as to bond covalently with the protamine.
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Fisher Richard V.
Jones W. Gary
The University of Michigan
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