Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1992-10-29
1993-10-19
Chan, Y. Christina
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530350, 530386, 536 2353, C07K 710, C12N 1513
Patent
active
052546713
ABSTRACT:
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for therapy and diagnosis. For example, antibodies or immunotoxins specific for the epitopes associated with the anchor domain of IgE can be used to selectively destroy or downregulate IgE-bearing lymphocytes, thus blocking IgE-mediated allergic reactions. Three different isoforms of the C-terminal segment of the human .epsilon. chain resulting from alternative mRNA splicings in the membrane exon region are disclosed, one of which is secreted and not membrane-bound.
REFERENCES:
Sun, L K et al. Transfectomas expressing both secreted and membrane-bound forms of chimeric IgE with anti-viral specificity. Journal of Immunology. 146:199-205, 1991.
Chang, T W et al. Monoclonal antibodies specific for human IgE-producing B cells: a potential therapeutic for IgE-mediated allergic diseass. Bio/Technology 8:122-126, 1990.
EPO Search Report.
Chan Y. Christina
Eisenchenk F. C.
Mirabel Eric P.
Tanox Biosystems, Inc.
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