Extracellular recording multiple electrode

Electricity: measuring and testing – Impedance – admittance or other quantities representative of... – Lumped type parameters

Reexamination Certificate

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C324S691000, C324S693000

Reexamination Certificate

active

06894511

ABSTRACT:
A multiple electrode for measuring electro-physiological characteristics of a biological specimen includes a plurality of micro-electrode provided on a first region on a substrate, and a reference electrode provided in a second region on the substrate. The reference electrode includes at least one stimulus reference electrode for applying an electrical signal to the plurality of micro-electrodes. Preferably, the reference electrode includes at least one measurement reference electrode for detecting an electrical signal from the plurality of micro-electrodes, and the stimulus reference electrode is electrically insulated from the measurement reference electrode. Preferably, the second region is placed at a distance from an outer edge of the first region, and surrounds the first region.

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“Multichannel Cell Membrance Potential Measuring System and Its Application to Cortical Development Study”, by H. Sugihara, et al., National Technical Report vol. 42, No. 2, Apr. 1996, pp. 260-267.
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“Estimation of Network Structure for Signal Propagations by the Analysis of Multichannel Action Potentials in Cultured Neural Networks”, by Konno, et al., pp. 999-1006, 1998.

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