Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1990-08-09
1992-05-19
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
536 11, 536123, C12P 1904, C07H 100
Patent
active
051148480
ABSTRACT:
An extracellular exopolymer endowed with immunomodulating properties is prepared by culturing the Bifidobacterium infantis longum strain deposited at the Institut Pasteur under No. I-885 in a suitable medium under anaerobic conditions. After the microorganisms are discarded from the culture medium, the exopolymer thus produced is isolated, concentrated and then precipitated by adding an organic solvent; finally the product resulting from the precipitation is lyophilized.
The exopolymer thus obtained possesses an activity on cellular as well as on humoral immunity, and could thus be used as an immunomodulating agent in any potential therapeutic application.
REFERENCES:
patent: 4435389 (1984-03-01), Mutai et al.
patent: 4645667 (1987-02-01), Hashimoto et al.
patent: 4797589 (1989-01-01), Nakaya et al.
Shimamura et al., Agric. Biol. Chem., vol. 54 (11), p. 2869, 1990.
"Structural Studies of Cell Wall Polysaccharides from Bifidobacterium breve YIT 4010 and Related Bifidobacterium Species", Journal of Biochemistry, vol. 102, No. 6, 1987, by Y. Habu et al., pp. 1423-1432.
Bauer Jacques
Farine Jean-Claude
Jofre Torroella Juan
Michelet Marie-Christine
Pares Farras Ramon
Brown Johnnie R.
Laboratoires OM S.A.
Webber Pamela S.
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