External therapeutic composition for dermatitis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514169, 514170, 514178, 514179, 514180, 514181, 514182, A61K 3156

Patent

active

058859780

ABSTRACT:
The present invention provides an external therapeutic composition for dermatitis comprising an aqueous solution including a therapeutically effective amount of an adrenal cortical steroid, a cyclodextrin, polysaccharides, and a carrier such as water, prepared by clathrating the adrenal cortical steroid in the cyclodextrin using a homomixer to form a clathrate, and adding the clathrate to an aqueous solution of polysaccharides, while being stirred uniformly, to dissolve the clathrate in the aqueous solution, as well as a method for the treatment of dermatitis in a mammalian subject, which comprises administering to said subject a therapeupically effective amount of the external therapeutic composition for dermatitis described above. The external therapeutic composition for dermatitis according to the present invention is extremely safe and can cure dermatitis such as an atopic dermatitis or the like without side effects.

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K. Uekama et al., "Inclusion Complexations of Steroid Hormones with Cyclodextrins in Water and in Solid Phase", Chemical Abstracts, vol. 96, No. 18, p. 411, Abstract No. 149046j, May 3, 1982.
Husa "Pharmaceutical dispensing" Husa Brothers Pub. p. 228, 1947.
Okada et al. "Some properties and the inclusionbehavio of branched cyclodextrins" chem. Pharm. Bull. v. 36, pp. 2176-2185, 1988.

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