Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-02-03
1998-10-06
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
A61K 3134, A61K 31195, A61K 31125, A61K 3107
Patent
active
058176217
DESCRIPTION:
BRIEF SUMMARY
This invention relates to the medical field, and particularly to cosmetology, to provide new effective cosmetic preparations, such as nutritional skin creams, which restores physiological functions to the skin.
BACKGROUND OF THE INVENTION
Searching for preparations and methods to maintain skin nutrition is an important problem in cosmetology. The skin's metabolism is the basis for its functional activity and regenerative ability.
The human skin is in close relationship with the internal organs and is also in constant interaction with the environment. Human skin acts as the interface between the environment and body and is always directly influenced by different environmental factors and variable parameters of human internal system. The skin regulatory mechanisms are always active and ready to induce systemic changes necessary to normalize any pathological event concerning skin morphology and activities. The trophic processes, which are responsible for the adequate consumption of energetic and plastic substances according to the increased needs of the skin, ensure morphological and functional stability of skin structures. The skin's nutrition is a determinative factor in the skin's viability, leading to healthy skin with the characteristics of elasticity, turgor, humidity, pigmentation, etc.
The skin uses not only its own resources, but also the resources from the entire body. There are presently different nutritional creams with different trophotropic and metabolic properties.
A well known cosmetic remedy containing equal quantities of lanolin, plant oil and water causes decreased heat emission from the skin, increased skin temperature; increased blood flow causes skin hyperemia activating skin metabolism followed by optimization of the skin functions (Yu. K. Skripkin, F. A. Zvierkova, G. Ya. Sharapova, A. A. Studnitsyn. Guide Book on Children Dermatology. Moscow, Medicina Publishing House, 1983, 476:64-66, 227, 314; in Russian). This effect may be enhanced by the addition of biologically active substances including vitamins, enzymes, amino acids, lecithin, tissues preparations, and other biologically active substances which stimulate skin metabolism and nutrition (N. B. Koroliova. In the: "Guide Book of Medicinal Cosmetology", ed. V. T. Glukbenki, Kyiv, Zdorovia Publishing House, 1989, 302: 86-97; in Russian). For patients with dry peeling skin with decreased turgor and elasticity, increased wrinkles and other indications of premature skin fading and aging, nutritional vitamin creams, such as vitamin A and E, are usually applied (T. V. Ptchiolkina, Ye. A. Sobolieva, I. G. Shishkina. In the: "Guide Book of Medicinal Cosmetology", Leningrad, Meditsina Publishing House, 1978, 176:15-16).
However, this well known vitamin-containing preparation does not assure a result because it does not have an adequate effect on tissues perfusion and nutritional homeostasis.
The preparation used in dermatology which is the most similar in its action to the preparation of the present invention contains the following: salicylic acid (2.4 mass %), lanolin (24.4 mass %), vaseline (24.4 mass %), vitamin A oil solution (24.4 mass %), and water (24.4 mass %) (Guide Book of Medicinal Cosmetology, ed. A. F. Abakhadze, Moscow, Medicina Publishing House, 1975, 253 p.p., p. 71). This preparation is aimed to abolish skin dryness, stiffness, and toughness caused by hyperkeratosis. Lanolin, vaseline and oil are used here as a fat ointment base, and vitamin A and salicylic acid, a oxybenzoic acid derivative, as skin ameliorating active substances.
The preparation has the defect of low effectiveness because: pathological condition; taken into account; also not taken into consideration; and restore damaged tissue structures cannot be achieved using such an ointment.
DISCLOSURE OF THE INVENTION
The goal of this invention is to find an external skin preparation containing an adequate combination of components assuring a set of physiological events. The tropho-metabolic activity of the preparation increases, due to adequate ingredients ra
REFERENCES:
patent: 4952560 (1990-08-01), Kigasawa et al.
patent: 5446070 (1995-08-01), Mantelle
Skripkin, et al. Handbook on Children's Dermatology, Moscow, "Medicina", pp. 64-66, 227, 314, (1983).
Koroleva, et al. "Reference Book on Medical Cosmetology", Zdorovje, pp. 86-97, (1989).
Ptcholkina et al. Reference Book on Medical Cosmetology, Leningrad, "Medicina", pp. 15-16, (1978).
Abakhadze, et al. (ed.) Reference Book on Medical Cosmetology, Moscow, "Medicina", p. 71, (1975).
Goudzenko Janna Prokofievna
Korotkaia Elena Valerievna
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