Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Embryonic structure
Patent
1988-04-18
1991-01-15
Stone, Jacqueline
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Embryonic structure
514460, A61K 3550, A61K 3135
Patent
active
049852558
ABSTRACT:
External preparations of 1 melanogenesisinhibitory agent contain, as active ingredients, a placental extract of pregnant cows and kojic acid or a derivative thereof. The placental extract of pregnant cows is a very effective melanogenesis-inhibitory substance, which acts through a mechanism different from that of the known extract of fully-matured human placenta and markedly diminishes the overall activity of tyrosinase isozymes (T.sub.1, T.sub.2 and T.sub.3). The external preparations, which utilize the synergistic effect between this unique substance and kojic acid or a derivative thereof (a known melanogensis-inhibitory substance), are effective for the relief and prevention of pigmentation diseases, such as liver spots.
REFERENCES:
Higa, cited in Chem. Abstracts, vol. 104:74818k, (1986).
Ichimaru Farukosu KK, cited in Chem. Abstracts, vol. 100:39578c, (1984).
Nagai et al., cited in Chem. Abstracts, vol. 96:11515e, (1982).
Sansho Seiyaku Co., Ltd.
Stone Jacqueline
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