Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-16
1999-12-28
Cook, Rebecca
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514643, 514725, A61K 700
Patent
active
060082461
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to an external preparation for skin and in particular, relates to an enhancer of betaine which has a moisturizing function and a skin improvement function.
BACKGROUND ART
A maintenance function of a beautiful skin state is one of the fundamental functions of an external preparation for skin such as cosmetics. In order to maintain this beautiful skin state, it is essential to condition the sulci cutis and cristae of the skin by preventing or improving a skin roughness.
In order to attain this object, various humectants such as glycerin, sorbitol, propylene glycol, polysaccharide, and the like have been compounded into cosmetics.
However, among these humectants, e.g., polysaccharide may cause precipitation in the formulation which contains a large amounts of alcohol. Cosmetics which are compounded with glycerin, sorbitol, propylene glycol, and the like in large amounts for the purpose of improving the moisturizing effect, have a tendency to be attended with the sticky feel of use.
In order to remove the sticky feel of use of the cosmetics which is attendant to the improvement of the moisturizing effect, an experiment of compounding trimethylglycine (quaternary ammonium salt) into a cosmetic has been done (cf. Japanese Unexamined Patent Publication Hei No. 6-293625).
A cosmetic which is compounded with trimethylglycine independently can reduce the sticky feel of use. However, in the case where trimethylglycine is compounded in the dosage which is enough to exhibit the improvement effect of the skin state that trimethylglycine is possessed, such an external preparation for skin has a tendency to be attended with "powdery feel of use" by the presence of trimethylglycine. Therefore, the external preparation for skin which is compounded trimethylglycine independently, does not sufficiently satisfy the requirements of users.
DISCLOSURE OF INVENTION
In view of the above-mentioned problem of the prior art, the object of the present invention is to provide an external preparation for skin which can sufficiently exhibit the moisturizing function and the skin improvement function of trimethylglycine.
As the result of diligent studies of the inventors for attaining the above-mentioned object, it has been found that coexistence with a specific high-molecular components or vitamins, can largely improve the moisturizing function and the skin improvement function that the low-molecular-weight betaine is normally possessed. Accordingly, the present invention has been accomplished.
Namely, the present invention provides an external preparation for skin comprising a quaternary ammonium salt which is shown by following constitutional formula (I), and, an enhancer of the moisturizing function, and the skin improvement function of a quaternary ammonium salt selected from the group consisting of vitamin E types, vitamin A derivatives, and alkyl denatured carboxyvinyl polymer. ##STR2## (wherein R.sup.1, R.sup.2, and R.sup.3 show alkyl groups having a carbon number from 1 to 6. A sum total of the carbon number of R.sup.1, R.sup.2, R.sup.3, and n is 8 or less. Each carbon number of R.sup.1, R.sup.2, and R.sup.3 can be same or different.)
Preferably, the compounding amount of the quaternary ammonium salt is in the range from 0.1% by weight to 30% by weight with respect to the whole amount of the external preparation.
More preferably, the compounding amount of the quaternary ammonium salt is in the range from 0.1% by weight to 20% by weight with respect to the whole amount of the external preparation.
Preferably, vitamin E types are tocopherol and/or vitamin E acetate.
Also preferably, the compounding amount of the vitamin E types is in the range from 0.0001% by weight to 2.0% by weight with respect to the whole amount of the external preparation.
More preferably, the compounding amount of the vitamin E types is in the range from 0.001% by weight to 0.5% by weight with respect to the whole amount of the external preparation.
Preferably, vitamin A derivatives are vitamin A ester.
Also
REFERENCES:
patent: 4000276 (1976-12-01), Hasunuma et al.
patent: 4490355 (1984-12-01), Desai
patent: 5384115 (1995-01-01), Bissett et al.
patent: 5580549 (1996-12-01), Fukuda et al.
CTFA Cosmetic Ingredient Dictionary, pp. 271, 374, 1982.
CA 121: 186797, Uno et al, May 10, 1994.
Inoue Haruhiko
Ito Kenzo
Nabeshima Hisaya
Sato Hiroyoshi
Shimada Tadahiro
Chao Fei-Fei
Cook Rebecca
Shiseido Co. Ltd.
Snider Ronald R.
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