Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2000-12-22
2002-03-05
Tate, Christopher R. (Department: 1651)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S757000, C424S401000, C514S547000
Reexamination Certificate
active
06352685
ABSTRACT:
This application claims the priority of the Japanese Patent Application No. 11-367587 filed on Dec. 24, 1999 and Japanese Patent Application No. 2000-29348 filed on Feb. 7, 2000, which are incorporated herein by reference.
FIELD OF THE INVENTION
The present invention relates to an external preparation for skin including an extract from a particular plant, and more particularly, to an improvement of anti-aging effect and whitening effect thereof.
BACKGROUND OF THE INVENTION
Generally, the external preparations for skin such as milky lotions, creams, lotions, packs, detergents, dispersion solutions, ointments, liquids for external use are including various active ingredients, to perform specified drug effect.
For example, external preparations for whitening include whitening ingredients of ascorbic acid, glutathione and hydroquinon etc., to prevent phenomenon of darkening caused by sunburn, brown spot and freckle etc. caused by pigmentation.
Also, cell activation agents of vitamin A, soybean extract and seaweed extract etc. are compounded in the external preparation for skin for the purpose of an anti-aging effect, to improve wrinkle, slack of skin caused by aging, ultraviolet rays exposure etc.
However, in the prior arts, the effects of the component for whitening or anti-aging were not sufficient. And, these components may be degraded in pharmaceutical preparation. Because of this, these conventional components are not sufficient to demonstrate desired drug effect. Therefore, improvements of these and new active ingredients have been desired.
SUMMARY OF THE INVENTION
The object of the invention is to provide better whitening or anti-aging effect by a high safety plant extract.
The present inventors have been conducted a search for natural components that have excellent drug effect and can use as an active ingredient of external preparation for skin, and found an extract from
Pueraria mirifica
, that is a plant in Southeast Asia, has high melanine formation inhibition and also anti-aging effect. Furthermore, the extract is effective when it is compounded in external preparation for skin as a whitening component or an anti-aging component. Also, excellent effects are obtained when other active ingredients are compounded with the extract. The inventors have completed the invention based on this finding.
Namely, an external preparation for skin according to the present invention includes an extract of
Pueraria mirifica.
Also, in said external preparation for skin, the extract of
Pueraria mirifica
is preferably compounded as a whitening component.
Also, an external preparation for whitening according to the present invention comprises;
(A) extract of
Pueraria mirifica;
(B) one or more active ingredient selected from the group consisting of a whitening agents, an anti-oxidant, an anti-inflammation agent and an ultraviolet-ray shielding ingredient.
Also, in said external preparation for skin, the extract of
Pueraria mirifica
is preferably compounded as an anti-aging component.
Also an external preparation for anti-aging according to the present invention includes the followings;
(A) the extract of
Pueraria mirifica;
(B) one or more effective ingredient selected from the group consisting of a cell activation agent, an anti-oxidant, a humectant, and an ultraviolet-ray shielding ingredient.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Pueraria mirifica
, of which extract is used as an active ingredient in the invention, is a plant grows in Southeast Asia. The plant belongs to
Legume lobata
and called Kwaao Khruea in Thailand.
Pueraria mirifica
includes various isoflavone derivatives that have female hormone effect. Therefore, it has been used as a Thailand medicine, private spice, herb, traditional medicine etc. heretofore.
The extract of the above plant used for the invention is obtained by extracting a dried root lump of said plant by using a proper extraction solvent. The method for preparation is not restricted but especially prepared by extracting under low temperature or room temperature to warming by using a proper solvent.
As for extraction solvent used in the invention, examples are as follows;
water; lower alcohol such as methyl alcohol, ethyl alcohol; liquid polyhydric alcohol such as glycerol, propylene glycol, 1,3-butylene glycol. One or more of these can be used for the extraction solvents.
Also, the example of the preferable extraction method is as follows. The extraction from
Pueraria mirifica
is carried out for 1 to 5 days with room temperature by 0~100 v/v % water content ethyl alcohol or 1,3-butylene glycol. This extract is filtered. The filtrate thus obtained was allowed for around 1 week for aging. The result was filtered again.
The compounding quantity of
Pueraria mirifica
extract in the external preparation for skin of this invention is preferably 0.00001~5 wt % (hereinafter indicated “%” only) as the dried solid in the composition. In the case where it is used as a whitening component, the compounding amount is more preferably 0.03~2%. In the case where it is used as an anti-aging component, the compounding amount is more preferably 0.0001~2%. Said plant extract can be stably compounded in this range and show a high effect. In the case where the extract is used as liquid, as long as the content of the dried solid in extract is in above range in the external preparation, the concentration is not restricted.
The
Pueraria mirifica
extract of this invention can be compounded with the various bases of usual external preparation for skin in accordance with common methods. The external preparation for skin can show excellent effect, by compounding with other active ingredients.
As for the active ingredients ((B) component) in combination with the
Pueraria mirifica
extract ((A) component), examples are as follows. In the case of a whitening use, the active ingredients may be other whitening agents, anti-oxidants, antiinflammation agents, ultraviolet-ray shielding ingredients etc. In the case of an anti-aging use, the active ingredient is a cell activation agent, anti-oxidants, humectants, ultraviolet-ray shielding ingredients etc. These concrete active ingredients are shown below, respectively.
Whitening Agent
As for whitening agent used in the invention, examples are as follows; vitamin C, its derivatives and salts thereof, placenta extract, licorice extract, coix seed extract, scutellaria root extract, seaweed extract etc. The whitening agents are not restricted as long as which has a whitening effect. In these whitening agents, vitamin C, its derivatives and salts thereof, and placenta extracts are preferable.
Anti-Oxidant
As for anti-oxidant used in the invention, examples are as follows; vitamins B, its derivatives and salts thereof, vitamin E, its derivatives and salts thereof, dibutylhydroxytoluene, dibutyl hydroxyanisol, mannitol, carotenoid such as astaxanthine, plant extract including flavonoid such as quercetin, quercitrin, ginkgo extract, scutellaria root extract, balm mint extract, saxifrage extract, Siberian ginseng extract, and Alnus firma Siebold. et Zucc. extract. In these anti-oxidant, vitamin E, its derivatives and salts thereof are preferable.
Anti-Inflammation Agent
As for anti-inflammation agent used in the invention, examples are as follows; glycyrrhizinic acid, glycyrrhetinic acid, those derivatives and those salts, aloe extract, perilla extract, mugwort extract and matricaria extract. In these anti-inflammation agents, glycyrrhizinic acid, glycyrrhetinic acid, those derivatives and those salts are preferable.
Ultraviolet-Ray Shielding Agent
As for ultraviolet-rays shielding agent used in the invention, examples are as follows; 2-ethylhexyl-p-methoxy cinnamate, oxybenzone, 4-tert-butyl-4′-methoxy dibenzoylmethane, titanium oxide, micronized particle titanium oxide, and zinc oxide. In these ultraviolet-ray shielding ingredients, 2-ethylhexyl-p-methoxy cinnamate, titanium oxide, micronized particle titanium oxide and zinc oxide are preferable.
Cell Activation Agent
As for cell activation agent used in the invention,
Higuchi Yoshihiro
Hoshino Taku
Moriyama Masahiro
Sakata Osamu
Chao Fei-Fei
Kose Corporation
Tate Christopher R.
Venable Baetjer Howard & Civiletti LLP
Winston Randall
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