Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1991-01-11
1992-01-21
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424456, 424484, 424485, 424486, 424443, 514861, 514863, 514781, 514179, 514182, 5147726, 5147724, A61L 1516, A61L 1522, A61K 3156, A61K 3174
Patent
active
050826638
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an external adhesive preparation containing steroids. More specifically, the present invention relates to an external adhesive preparation containing steroids which is obtained by incorporating a steroid useful for the treatment of skin diseases into an adhesive gel base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent and spreading the resulting composition onto a soft support, said preparation being directly applied to diseased parts on the skin so that the contained steroids are administered to the skin for treatment of the diseases.
PRIOR ART
Hitherto, for the treatment of allergic skin diseases such as eczema, hives, children's strophulus, contoured exudative erythema, Behcet's syndrome, keratodermia palmaris, psoriasis and the like, there have been used oral preparations, injections, external preparations and the like containing cortisone etc. as an active component.
However, these preparations have some side effect or inconvenience in usage. For example, in case of oral preparations, there is a fear of forgetting taking or an excess administration. In case of injections, patients suffer from pain or stress when administering drugs and further it is difficult to be administered by the patients themselves. External preparations such as ointments or lotions not only stain clothes and the like but also are hardly administered in a fixed-amount. Further, in case of external preparations, patients are forced to be given by a physical stimulus to the diseased parts which are most accompanied with urtication and this stimulus sometimes makes worse symptoms. Therefore, the external preparations are not necessarily suitable. For the purpose of obviating the above-mentioned disadvantages, there have been developed tapes which are produced by incorporating a steroid into a pressure sensitive adhesive comprising a natural gum or a copolymer of acrylic acid ester - acrylic acid. These tapes are more advantageous than conventional external preparations in many respects, i.e. they may have an effect similar to occlusive dressing technique by applying them to diseased parts, and they are more easily handled in such a treatment method. However, the application of these tapes to diseased parts induces occasionally contact dermatitis caused by the adhesive itself, folliculitis caused by bacteria etc. on the skin, or cutaneous inflammation due to stimulus of sweat glands. Furthermore, these tapes are still unsatisfactory in that when these tapes are removed, diseased parts are rather injured or keratin is peeled off, and therefore not only is it difficult to apply them successively, but also symptoms may be made worse.
OBJECT OF THE INVENTION
As a result of the present inventors' intensive study to obviate defects of these tapes and the like, it has been found that an excellent adhesive preparation, without defects as seen in the conventional tapes, could be obtained by incorporating a steroid as the active ingredient into an adhesive base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent, and spreading this base on a soft support, and thus, the present invention has been accomplished. That is, the present invention provides an external adhesive preparation which is prepared by incorporating a steroid into an adhesive gel base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent.
BRIEF EXPLANATION OF THE DRAWING
FIG. 1 is a graph showing a cumulative release rate of active agent as to the adhesive preparations of the present invention prepared in Examples 1 and 2 and tapes prepared in Comparative Examples 1 to 3.
DISCLOSURE OF THE INVENTION
The water-soluble high molecular weight compound employed in the external adhesive preparations of the present invention includes gelatin, agar, alginic acid, mannan, carboxymethylcellulose, methylcellulose, po
REFERENCES:
patent: 3928261 (1975-12-01), Ashidaga et al.
patent: 4008321 (1977-02-01), Kamishita et al.
patent: 4755983 (1988-08-01), Takayanagi et al.
Patent Abstracts of Japan, vol. 9, No. 28 (C-264) (1751) Feb. 6, 1985.
Ishihara Manabu
Iwasa Akira
Kawaji Toshikuni
Konishi Ryoji
Makaya Osami
Moezie F. T.
SS Pharmaceutical Co., Ltd.
Teikoku Seiyaky Co., Ltd.
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