Extendin derivatives

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Glucagon; related peptides

Reexamination Certificate

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Details

C530S300000, C530S303000, C530S322000, C530S324000, C530S345000, C530S399000, C530S402000, C514S002600, C514S003100, C514S012200, C514S023000, C514S866000

Reexamination Certificate

active

09886311

ABSTRACT:
The present invention relates to novel derivatives of exendin-4 or exendin-4 fragments, wherein the derivatives have a lipophilic substituent attached, optionally via a spacer, to an amino acid residue, which is not the N-terminal or C-terminal amino acid residue of the derivative.

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Bowie et al., Science, vol. 247, pp. 1306-1310, 1990.
Houghten et al., Vaccines 86, Cold Spring Harbor Laboratory, pp. 21-25, 1986.

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