Extended stability formulations for paclitaxel

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514511, 514529, 514532, 514533, 514534, 514650, 514651, 514656, A61K 31335, A61K 3134, A61K 950, A01N 4302

Patent

active

056818467

ABSTRACT:
The present invention is directed to improved pharmaceutical compositions employing paclitaxel that are formulated to increase stability and solubility. These improved formulations are useful in long-term, multi-day continuous infusion protocols, and have the advantage of reducing the number of infusion system breaks during the entire period of drug administration. Also disclosed are kits for use in preparing paclitaxel for long-term infusion and enhanced solubility.

REFERENCES:
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Pfeifer and Hale, "Precipitation of paclitaxel during infusion by pump," Am. J. Hosp. Pharm., 50:2518-2521, Dec., 1993.
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Sharma and Straubinger, "Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes," Pharm. Res., 11(6):889-896, 1994.
Trissel and Bready, "Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection," Am. J. Hosp. Pharm., 49:1716-1719, Jul., 1992.
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Waugh et al., "Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers," Am. J. Hosp. Pharm., 48:1520-1524, Jul., 1991.

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