Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-03-17
1997-10-28
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514511, 514529, 514532, 514533, 514534, 514650, 514651, 514656, A61K 31335, A61K 3134, A61K 950, A01N 4302
Patent
active
056818467
ABSTRACT:
The present invention is directed to improved pharmaceutical compositions employing paclitaxel that are formulated to increase stability and solubility. These improved formulations are useful in long-term, multi-day continuous infusion protocols, and have the advantage of reducing the number of infusion system breaks during the entire period of drug administration. Also disclosed are kits for use in preparing paclitaxel for long-term infusion and enhanced solubility.
REFERENCES:
patent: 5403858 (1995-04-01), Bastard et al.
patent: 5438072 (1995-08-01), Bobee et al.
Alkan-Onyuksel et al., "A Mixed Micellar Formulation Suitable for the parenteral Administration of Taxol," Pharm. Res., 11:206-212, 1994.
Mathew et al., "Synthesis and Evaluation of Some Water-Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity," J. Med. Chem., 35:145-151, 1992.
Nicolaou et al., "Design, synthesis and biological activity of protaxols," Nature, 364:464-466, 1993.
Pfeifer and Hale, "Precipitation of paclitaxel during infusion by pump," Am. J. Hosp. Pharm., 50:2518-2521, Dec., 1993.
Rowinsky and Donehower, "The Clinical Pharmacology of Paclitaxel (TAXOL.RTM.)," Seminars in Oncol., 20:16-25, Aug., 1993.
Sharma and Straubinger, "Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing Liposomes," Pharm. Res., 11(6):889-896, 1994.
Trissel and Bready, "Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection," Am. J. Hosp. Pharm., 49:1716-1719, Jul., 1992.
Trissel and Martinez, "Turbidimetric assessment of the compatibility of taxol with 42 other drugs during simulated Y-site injection," Am. J. Hosp. Pharm., 50:300-304, Feb., 1993.
Waugh et al., "Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers," Am. J. Hosp. Pharm., 48:1520-1524, Jul., 1991.
Board of Regents , The University of Texas System
Nutter Nathan M.
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