Extended human hematopoiesis in a heterologous host

Details Extended human hematopoiesis in a heterologous host Extended human hematopoiesis in a heterologous host

1992-02-13

2000-07-25

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435325, 435373, A01K 6700, C12N 500

Patent

active

060938722

ABSTRACT:
A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate site of a young immunocompromised mouse at a site supplied with a vascular system, whereby the fetal tissue results in novel formation of functional human bone marrow tissue.

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patent: 5625127 (1997-04-01), Kaneshima et al.
Pollard, Tokai J. Exp. Clin. Med. 10 (2,3) : 175-179 (1985).
Wade et al., Transplantation 44 (1) : 88-92 (1987).
Fohlmeister et al., Nat. Immun. Cell Growth Regul. 4 : 221-228 (1985).
McCune et al., Science 241 : 1632-1639 (1988).

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