Extended human hematopoiesis in a heterologous host

Details Extended human hematopoiesis in a heterologous host Extended human hematopoiesis in a heterologous host

1994-05-17

1995-12-19

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

424553, 424580, 424582, 424577, 424520, 424578, 800DIG2, 800DIG5, A61K 3500

Patent

active

054769973

ABSTRACT:
A human hematopoietic system is provided in an immunocompromised mammalian host, where the hematopoietic system is functional for extended periods of time. Particularly, human fetal liver tissue and human fetal thymus is introduced into an appropriate site of a young immunocompromised mouse at a site supplied with a vascular system, whereby the fetal tissue results in novel formation of functional human bone marrow tissue.

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Wade et al., Transplantation 44(1):88-92 (1987).
Fohlmeister et al., Nat. Immun. Cell Growth Regul. 4:221-228 (1985).
McCune et al., Science 241:1632-1639 (1988).
Povlsen et al., Nature 248:247-249 (1974).
Bosma et al., Nature 301:527-530 (1983).
Mosier et al., Nature 335:256-259 (1988).

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