Extended focal region measuring apparatus and method

Details Extended focal region measuring apparatus and method Extended focal region measuring apparatus and method

2004-11-24

2011-12-13

Winakur, Eric (Department: 3777)

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

C356S124000, C600S310000

Reexamination Certificate

active

08078245

ABSTRACT:
A method and apparatus for measuring an apparent depth of a section of an animal body are disclosed. Light is focused concurrently to an extended focal region comprising a plurality or continuum of measurement locations. Light reflected by a refractive index interface coincident with one of the plurality of measurement locations is detected. Detected light signals are generated from light reflected from first and second interfaces respectively defining the section under investigation, so that the apparent positions of the interfaces may be derived. A confocal arrangement and an axicon element may be employed. Preferably, the section is the aqueous humor of an eye. From changes in its refractive index corresponding changes in glucose concentration in the aqueous humor and, in turn, in the bloodstream of a patient may be derived, offering a non-invasive monitoring means for diabetic patients. Other compounds and structures of the body may alternatively be investigated.

REFERENCES:
patent: 3958560 (1976-05-01), March
patent: 3963019 (1976-06-01), Quandt
patent: 4014321 (1977-03-01), March
patent: 4154114 (1979-05-01), Katz
patent: 4407008 (1983-09-01), Schmidt
patent: 4750830 (1988-06-01), Lee
patent: 4806004 (1989-02-01), Wayland
patent: 5152759 (1992-10-01), Parel et al.
patent: 5209231 (1993-05-01), Cote
patent: 5433197 (1995-07-01), Stark
patent: 5553617 (1996-09-01), Barkenhagen
patent: 5582168 (1996-12-01), Samuels
patent: 5785651 (1998-07-01), Kuhn
patent: 5820557 (1998-10-01), Hattori
patent: 5880465 (1999-03-01), Boettner
patent: 5961449 (1999-10-01), Toida
patent: 6066847 (2000-05-01), Rosenthal
patent: 6152875 (2000-11-01), Hakamata
patent: 6181957 (2001-01-01), Lambert
patent: 6187599 (2001-02-01), Asher
patent: 6188477 (2001-02-01), Pu
patent: 6267477 (2001-07-01), Karpol
patent: 6382794 (2002-05-01), Lai
patent: 6424850 (2002-07-01), Lambert
patent: 6442410 (2002-08-01), Steffes
patent: 6574501 (2003-06-01), Lambert
patent: 6585723 (2003-07-01), Sumiya
patent: 6836337 (2004-12-01), Cornsweet
patent: 6853854 (2005-02-01), Proniewicz
patent: 6934035 (2005-08-01), Yang
patent: 6961599 (2005-11-01), Lambert
patent: 2002/0171804 (2002-11-01), Rathjen
patent: 2003/0211625 (2003-11-01), Cohan
patent: 2003/0225321 (2003-12-01), Cote
patent: 2003/0233036 (2003-12-01), Ansari
patent: 2004/0080759 (2004-04-01), Shaver
patent: 2004/0087843 (2004-05-01), Rice
patent: 2004/0138539 (2004-07-01), Jay
patent: 2004/0152963 (2004-08-01), March
patent: 2004/0257585 (2004-12-01), Cornsweet
patent: 2004/0260159 (2004-12-01), Gerlitz
patent: 0589191 (1984-08-01), None
patent: 2 144 537 (1985-03-01), None
patent: WO 93/07801 (1993-04-01), None
patent: WO 97/13448 (1997-04-01), None
patent: 97/30627 (1997-08-01), None
patent: WO 99/44496 (1999-09-01), None
patent: WO 00/60350 (2000-10-01), None
patent: WO 2004/034894 (2004-04-01), None
patent: WO 2004/064628 (2004-08-01), None
patent: WO 2005/120334 (2005-12-01), None
Anumula, H., Nezhuvingal, A., Li, Y., Cameron, B., “Development of a Non-invasive Corneal Birefringence Compensated Glucose Sensing Polarimeter”, Proc. SPIE vol. 4958, p. 303-312, Advanced Biomedical and Clinical Diagnostic Systems, Jul. 2003.
Arnold, M., “Noninvasive Laser Measurement of Blood Glucose in the Eye: A Bright idea or an Optical Illusion”, Diabetes Technology and Therapeutics, vol. 1, No. 2, 1999.
Baba, J., Cameron, B., Cote, G., “Effect of temperature, pH, and corneal birefringence on polarimetric glucose monitoring in the eye”, Journal of Biomedical Optics 7(3), 321-328 (Jul. 2002).
Baba, J., Cote, G., “Dual-detector polarimetry for Compensation of Motion Artifact in a Glucose Sensing System”, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, Proc. SPIE vol. 4624 (2002), pp. 76-80.
Bockle, S., Rovati, L., Ansari, R., “Polarimetric glucose sensing using the Brewster-reflection off the eye lens: theoretical analysis”, Proceedings of SPIE—vol. 4624 Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, May 2002, pp. 160-164.
Borchert M, Storrie-Lombardi M, Lambert J “A non-invasive glucose monitor: preliminary results in rabbits” Diabetes Technology & Therapeutics 1999; 1: 145-151.
Cameron, B., Gorde, M., Satheesan, B., Cote, G., “The Use of Polarized Laser Light Through the Eye for Noninvasive Glucose Monitoring”, Diabetes Technology and Therapeutics, vol. 1, No. 2, 1999.
Chou C, Lin P-K “Noninvasive glucose monitoring with optical heterodyne Technique” Diabetes Technology & Therapeutics 2000; 2: 45-47.
Cote, G., “Non-Invasive and Minimally Invasive Optical Monitoring Technologies”, Symposium of Innovative Non- or Minimally Invasive Technologies for Monitoring Health and Nutritional Status in Mothers and Young Children, Aug. 2000, Children's Research Center, Baylor College of Medicine, Houston, TX.
Khalil, O., “Non-Invasive Glucose Measurement Technologies: An Update from 1999 to the Dawn of the New Millennium”, Diabetes Technology and Therapeutics, vol. 6, No. 5, 2004, pp. 660-697.
Li, H., Petroll, W., Moller-Pederson, T., Maurer, J, Cavanagh, H., Jester, J., “Epithelial and Corneal Thickness Measurements by in vivo confocal microscopy through focusing (CMTF)”, Current Eye Research; (16): 214-221, 1997.
Li, J., Jester, J., Cavanagh, H., Black, T., Petroll, W., “On-Line 3-Dimensional Confocal Imaging in Vivo”, Investigative Ophthalmology and Visual Science, Sep. 2000, vol. 41, No. 10, pp. 2945-2953.
Liu, J., Bagherzadeh, M., Hitzenberger, C., Pircher, M., Zawadzki, R., Fercher, A., “Glucose dispersion measurement using white-light LCI”, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, Proceedings of the SPIE, vol. 4956, pp. 348-351 (2003).
March, W., “Analysis: A Noninvasive Ocular Glucose Sensor”, Diabetes Technology & Therapeutics, Jun. 2001, vol. 3, No. 2: 209-210.
March, W., Mueller, A., Herbrechtsmeier, P., “Clinical Trial of a Non-invasive Contact Lens Glucose Sensor”, Diabetes Technology and Thrapeutics, vol. 6, No. 6, 2004, pp. 782-789.
March, W., Ochsner, K., Horna, J., “Intraocular Lens Glucose Sensor”, Diabetes Technology & Therapeutics, May 2000, vol. 2, No. 1: 27-30.
Masters, B. and Bohnke, M., “Three-Dimensional Confocal Microscopy of the Living Human Eye”, Annu. Rev. Biomed. Eng. 2002, 4:69-91.
McLaren, J., Nau, C., Erie, J., Bourne, W., “Corneal Thickness Measurement by Confocal Microscopy, Ultrasound, and Scanning Slit Methods”, American Journal of Ophthalmology, Jun. 2004, pp. 1011-1020.
McLaren, J., Nau, C., Erie, J., Bourne, W., “Corneal Thickness Measurement by Confocal Microscopy, Ultrasound, and Scanning Slit Methods”, American Journal of Ophthalmology, Feb. 2005, pp. 391-392, Editorial Response.
Rawer, R., Stork, W., Kreiner, C., “Non-invasive polarimetric measurement of glucose concentration in the anterior chamber of the eye”, Graefe's Arch Clin Exp Ophthalmol (2004) 242: 1017-1023.
Schrader W, Meuer P, Popp J, Kiefer W, Menzebach J-U, Schrader B “Non-invasive glucose determination in the human eye” Journal of Molecular Structure 2005; 735-736: 299-306.
Sebag, J., Ansari, R., Dunker, S., Suh, K., “Dynamic Light Scattering of Diabetic Vitreopathy”, Diabetes Technology and Therapeutics, vol. 1, No. 2, 1999.
Steffes P “Laser-based measurement of glucose in the ocular aqueous humor: an efficacious portal for determination of serum glucose levels” Diabetes Technology & Therapeutics 1999; 1: 129-133.
Wicksted JP, Erckens RJ, Motamedi M, and March WF. “Raman spectroscopy studies of metabolic concentrations in aqueous solutions and aqueous humor specimens” Applied Spectroscopy 49:987-993, 1995.

Affiliated with

Also associated with

Rating

Extended focal region measuring apparatus and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Extended focal region measuring apparatus and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Extended focal region measuring apparatus and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4314168