Extended cycle multiphasic oral contraceptive kit

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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Reexamination Certificate

active

07935691

ABSTRACT:
A multiphasic contraceptive kit for use to practice a multiphasic method of contraception that provides for sequentially administering to a female of child bearing age: (a) a Phase I composition containing a progestogen and an estrogen for about 4 to about 7 days; (b) a Phase II composition containing a progestogen and an estrogen for about 8 to about 16 days; (c) a Phase III composition containing a progestogen and an estrogen for about 4 to about 7 days; and (d) optionally, a Phase IV composition which is a placebo or a non-steroidal component, wherein the ethinyl estradiol equivalent amount of estrogen in the Phase II composition is at least 5 mcg greater than the ethinyl estradiol equivalent amount of estrogen in each of the Phase I and III compositions. Preferably the sequential administration is repeated the day following the completion of the administration of the Phase III compositions providing an extended cycle multiphasic oral contraceptive method.

REFERENCES:
patent: 4390531 (1983-06-01), Edgren
patent: 4621079 (1986-11-01), Lachnit-Fixson et al.
patent: 4921843 (1990-05-01), Pasquale
patent: 4962098 (1990-10-01), Boissonneault
patent: 5010070 (1991-04-01), Boissonneault
patent: 5888543 (1999-03-01), Gast
patent: 5898032 (1999-04-01), Hodgen
patent: 2003/0139381 (2003-07-01), Bell et al.
patent: 2004/0220152 (2004-11-01), Ben-Maimon et al.
patent: WO98/04268 (1998-05-01), None
Edwards, L.A. “An Update on Oral Contraceptive Options”, Formulary 2004 United States, vol. 39, No. 2, Feb. 2004 pp. 104-121.
Hamerlynck J.V. Th et al. “Postponement of Withdrawal Bleeding in Women Using Low-Dose Combined Oral Contraceptives” Contraception, Geron-X, Inc., Los Altos, Ca, US, vol. 35, No. 3, 1987 pp. 199-206.

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