Extended chain derivatives of somatostatin

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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2601125S, A61K 3700, C07C10352

Patent

active

040815307

ABSTRACT:
Compounds of the formula 1 or 1a ##STR1## wherein R.sup.1 is H--, H--Gly or H--Leu and R.sup.2 is H or COOH and pharmaceutically acceptable salts thereof, are disclosed. The compounds of formulae 1 and 1a are useful for the management of diabetes and the treatment of acromegaly. Methods for their use are also disclosed.

REFERENCES:
patent: 3904594 (1975-09-01), Guillemin et al.
patent: 3917578 (1975-11-01), Immer et al.
patent: 3917581 (1975-11-01), Immer et al.
patent: 3931140 (1976-01-01), Sarantakis

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