Expression vectors for treating bacterial infections

Details Expression vectors for treating bacterial infections Expression vectors for treating bacterial infections

2004-12-14

2010-02-02

Mondesi, Robert B (Department: 1645)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C530S300000, C435S471000, C435S440000, C435S071100, C435S070100

Reexamination Certificate

active

07655775

ABSTRACT:
The present invention is compositions and methods for producing anti-bacterial polypeptides, and for using those compositions and methods for treating diseases and conditions caused by a bacterial infection. More specifically, the compositions and methods include treating a gram-negative bacterium with a gram-positive host that produces a polypeptide effective against the gram-negative bacterium.

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Gilson, L. et al., “Genetic analysis of an MDR-like export system: the secretion of colicin V.” EMBO Journal, 1999, pp. 3875-3884, vol. 9, No. 12.
Horn, N. et al, “Nisin-contolled production of pediocin PA-1 and colicin V in nisin-and non-nisin-producing Lactococcus lactis strains”, Applied and Environmental Microbiology, Aug. 2004, pp. 5030-5032, vol. 70, No. 8.
McCormick, J.K. et al., “Colicin V can be produced by lactic acid bacteria.” Letters in Applied Microbiology, 1991, pp. 37-41, vol. 29.
Pinou, T. et al., “Nucleotide polymorphism in microcin V plasmids”, Plasmid, 2001, pp. 1-9, vol. 46.
Riley, M.A. et al., “Bacteriocins: evolution, ecology, and application”, Annual Review of Microbiology, 2002, pp. 117-137, vol. 56, Dec. 1, 2008.
Stahl, C.H. et al., “Inhibitory Activities of colicin againstEscherichia colistrains responsible for postweaning diarrhea and edema disease in swine”, Antimicrobial Agents and Chemotherapy, Aug. 2004, pp. 3119-3121, vol. 48, No. 8.

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