Expression vectors encoding recombinant proteins comprising a VP

Details Expression vectors encoding recombinant proteins comprising a VP Expression vectors encoding recombinant proteins comprising a VP

1995-09-07

2000-03-28

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Vector, per se

435325, 435440, 435455, 514 44, C12N 1500, C12N 500, C12N 1563, A61K 4800

Patent

active

060430818

ABSTRACT:
The present invention relates to a Vpr protein, a Vpx protein or fragments thereof which permit the development of chimeric molecules that can be specifically targeted into the mature HIV-1 and HIV-2 virions to affect their structural organization and/or functional integrity, thereby resulting in gene therapy for HIV-1 and HIV-2 infections. The present invention also relates to Vpr/Vpx protein fragments, p6 protein, p6 protein fragment, or functional derivatives thereof which interfere with the native Vpr/Vpx incorporation into HIV-1 and HIV-2 virions. The present invention also relates to treatment of HIV-1 and HIV-2 infections based on the proteins of the present invention.

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