Chemistry: molecular biology and microbiology – Vector – per se
Patent
1995-01-20
1997-08-12
Ketter, James
Chemistry: molecular biology and microbiology
Vector, per se
4351723, 43525233, 536 235, 536 237, 536 241, C12N 1570, C12N 121, C07H 2104
Patent
active
056564953
ABSTRACT:
Expression vectors for human topoisomerase I and a method for detecting poisons of human topoisomerase I. The vector preferably contains a promoter, DNA coding for human topoisomerase I, DNA coding for a selectable marker, an origin of replication, and lac I.sup.q DNA which encodes a repressor for the promoter.
REFERENCES:
Stark et al. Multicopy expression vectors carrying the lac repressor gene for regulated high-level expression of genes in Escherichia coli. Gene vol. 51 255-267 1987.
S.T. Taylor et al., Gene, vol. 167, Nos. 1 and 2, pp. 69-74, 1995.
E. Rubin et al., Journal of Biological Chemistry, vol. 269, No. 4, pp. 2433-2439, 1994.
P. Benedetti et al., Cancer Research, vol. 53, No. 18, pp. 4343-4348, 1993.
P. D'Arpa et al., Proc. Natl. Acad. Sci. USA, vol. 85, pp. 2543-2547, 1988.
A. M. Knab et al., Journal of Biological Chemistry, vol. 268, No. 30, pp. 22322-22330, 1993.
D. Grana et al., Genetics, vol. 120, pp. 319-327, 1988.
Madden et al. Overexpression of human topoisomerase I in baby hamster kidney cells: hypersensitivity of clonal isolates to camptothecin Cancer Research vol. 52 525-532 1992.
Prentki et sl. In vitro insertional mutagenesis with a selectable DNA fragment Gene vol. 29 303-313 1984.
Y-H. Hsiang et al., Journal of Biological Chemistry, vol. 260, No. 27, pp. 14873-14878, 1985.
B. A. Sampson et al., Genetics, vol. 122, pp. 491-501, 1989.
R. Menzel et al., Cell, vol. 34, pp. 105-113, 1983.
G. J. Pruss et al., Cell, vol. 31, pp. 35-42, 1982.
S. DiNardo et al., Cell, vol. 31, pp. 43-51, 1982.
J. W. Little et al., Cell, vol. 29, pp. 11-22, 1982.
M-A. Bjornsti et al., Cancer Research, vol. 49, pp. 6318-6323, 1989.
L. Zumstein et al., J. Mol. Biol., 191, pp. 333-340, 1986.
M. D. Been et al., J. Mol. Biol., 180, pp. 515-531, 1984.
K. Kirkegaard et al., J. Mol. Biol., 15, pp. 625-637, 1985.
H. Hiasa et al., Journal of Biological Chemistry, vol. 269, pp. 2093-2099, 1994.
G. C. Walker, Microbiological Reviews, vol. 48, No. 1, pp. 60-93, 1984.
O. Huisman et al., Nature, vol. 290, pp. 797-799, 1981.
M.-A. Bjornsti et al., Proc. Natl. Acad. Sci. USA, vol. 84, pp. 8971-8975, 1897.
J. C. Wang, Ann. Rev. Biochem., 54, pp. 665-697, 1985.
H. A. DeBoer et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 21-25, 1983.
J. C. Wang et al., Nucleid Acids Research, vol. 11, No. 6, pp. 1773-1790, 1983.
C. J. Kenyon et al., J. Mol. Biol., 160, pp. 445-457, 1982.
J. C. Wang, J. Mol. Biol., 55, pp. 523-533, 1971.
E. Kjeldsen et al., Journal of Biological Chemistry, vol. 263, No. 8, pp. 3912-3916, 1988.
J.C. Wang, Biochemica et Biophysica Acta, 909, pp. 1-9, 1987.
K. Drlica et al., Biochemistry, vol. 27, No. 7, pp. 2253-2259, 1988.
E. Durban et al., Biochemical and Biophysical Research Communications, vol. 111, No. 3, pp. 897-905, 1983.
W. A. Baase et al., Biochemistry, 13, pp. 4299-4303, 1974.
R. E. Depew et al., Journal of Biological Chemistry, vol. 253, No. 2, pp. 511-518, 1976.
J. J. Champoux, Proc. Natl. Acad. Sci. USA, vol. 74, No. 9, pp. 3800-3804, 1977.
Y. Pommier et al., Journal of Biological Chemistry, vol. 266, No. 16, pp. 9418-9422, 1990.
Menzel Rolf
Taylor Scott T.
Bristol--Myers Squibb Company
Brusca John S.
Ketter James
Savitsky Thomas R.
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