Expression systems utilizing autolyzing fusion proteins and a re

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435189, 435212, 530350, A61K 3843, C12N 902, C12N 948, C07K 100

Patent

active

059550724

ABSTRACT:
The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system can be used to express a novel polypeptide which we have designated KM31-7 protein and which is capable of reducing dichloroindophenol and reduced glutathione. This polypeptide is useful in the treatment of disorders caused by oxidative stress.

REFERENCES:
patent: 5149783 (1992-09-01), Sommergruber et al.
patent: 5162601 (1992-11-01), Slightom
Chang et al. (1988) Phytopathology 78: 1266-1275.
Dougherty et al. (1990) In Viral Genes and Plant Pathogenesis, Pirone, TP and JG Shaw, eds. Springer-Verlag, New York.
Hopp et al. (1988) Bio/Technology 6: 1204-1210.
Database EMBL, Heidelberg, BRD, AC H11561, Jul. 3, 1995, Hillier, L. et al.: "The WashU-Merck EST Project", XP002025149, (abstract).
Pamela Y. Gasdaska, John R. Gasdaska, Shawn Cochran and Garth Powis, FEBS Letters, vol. 373, No. 1, Oct. 2, 1995, pp. 5-9, "Cloning and Sequencing of a Human Thioredoxin Reductase".
K. Boye, et al., Plant Molecular Biology, 18, 1203-1205, 1992, "cDNA cloning and sequencing of the bean yellow mosaic virus nuclear inclusion protein genes".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Expression systems utilizing autolyzing fusion proteins and a re does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Expression systems utilizing autolyzing fusion proteins and a re, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Expression systems utilizing autolyzing fusion proteins and a re will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-77517

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.