Expression systems for making single-chain monellin analogs

Details Expression systems for making single-chain monellin analogs Expression systems for making single-chain monellin analogs

1993-11-02

1996-01-30

Jones, W. Gary

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4352404, 4352532, 4353201, 536 236, C12P 2106, C12N 506, C12N 1503, C07H 2104

Patent

active

054879833

ABSTRACT:
Single-chain analogs of the naturally occurring two-chain peptide monellin retain the sweetening properties of the natural protein and are stable under conditions which would otherwise destabilize the native peptide. A covalent linkage joins peptides corresponding to portions of the A and B chains of the naturally occurring protein.

REFERENCES:
patent: 5234834 (1993-08-01), Fischer et al.
Ogata, C. et al. Nature (1987) 328: 739-742.
Protein Stability & Stabilization Through Protein Engineering, Nosoh et al., 1991, Ellis Horwood, pub., N.Y. p. 62.

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