Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-01-27
1996-07-23
Martinell, James
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 691, C12N 1506, C12N 1585, C12P 2100
Patent
active
055388850
ABSTRACT:
Expression systems which comprise a mammalian host, such as erythroid cells, transformed with a vector which comprises a promoter, a DNA sequence which codes for a desired polypeptide and a dominant control region. The vectors and methods for preparing polypeptides using the expression systems are also described. In a preferred embodiment, the vector contains cDNA for the desired polypeptide and a sequence which is capable of stabilising mRNA produced from the cDNA. The expression systems are particularly efficient and are capable of secreting the desired polypeptide.
REFERENCES:
patent: 4663281 (1987-05-01), Gillies et al.
Nevins. Ann. Rev. Biochem. 1983, (52) 441-466.
Antoniou Michael
Gooding Clare
Grosveld Franklin G.
Hollis Melvyn
Needham Maurice R. C.
Imperial Chemical Industries plc
Martinell James
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