Expression system for RSV glycoprotein F and G

Details Expression system for RSV glycoprotein F and G Expression system for RSV glycoprotein F and G

1992-11-20

1994-02-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 4353201, 4351723, 435 697, 4352542, 43525233, 536 234, 935 69, 935 70, 935 72, C12N 510, C12N 121, C12N 119

Patent

active

052886301

ABSTRACT:
This invention encompasses DNA compositions encoding novel chimeric glycoproteins which are useful for preparing virus specific immune responses against human respiratory syncytial virus. The DNA compositions include structural genes coding for the glycoproteins and expression and replication plasmids containing the structural genes. Host cells transformed with the above DNA compositions, vaccines made from the glycoproteins and methods for protecting humans by inoculation with said vaccines are also part of this invention.

REFERENCES:
patent: 4855224 (1989-08-01), Berman et al.
patent: 5001230 (1991-03-01), Brown et al.
Walsh, E. E. et al., "Protection from Respiratory Syncytial Virus Infection in Cotton Rats by Passive Transfer of Monoclonal Antibodies," Infection and Immunity 43(2):756-58 (1984).
Prince, G. A. et al., "Mechanisms of Immunity to Respiratory Syncytial Virus in Cotton Rats," Infection and Immunity 42(1):81-87 (1983).
Collins, P. L. et al., "Nucleotide sequence of the gene encoding the fusion (F) glycoprotein of human respiratory syncytial virus," Proc. Natl. Acad. Sci. 81;7683-87 (1984).
Brideau, R. J. et al., "Protection of Cotton Rats against Human Respiratory Syncytial Virus by Vaccination with a Novel Chimeric FG Glycoprotein," J. Gen. Virol. 70:2637-44 (1989).
Sullender, W. M. et al., "The Respiratory Syncytial virus Subgroup B Attachment Glycoprotein: Analysis of Sequence, Expression from a Recombinant Vector, and Evaluation as an Immunogen against Homologous and Heterologous Subgroup Virus Challenge," Virology 178:195-203 (1990).

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