Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-06-30
2000-08-08
Carlson, Karen Cochrane
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435325, 4352503, 4353201, 536 231, 530350, C12P 2106, C07H 1700, C07K 1400
Patent
active
061000620
ABSTRACT:
The use of HSCLOCK polypeptides and polynucleotides in the design of protocols for the treatment of sleep disorders, jet lag, pathologies that occur in advanced age, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.
REFERENCES:
patent: 5874241 (1999-02-01), Takahashi et al.
GenBank Accession No. AB002332.
GenBank Accession No. AF000998.
King, David P., et al., "Positional Cloning of the Mouse Circadian Clock Gene", Cell, vol. 89:641-653 (1997).
Nagase, Takahiro, et al., "Prediction of the Coding Sequences of Unidentified Human Genes. VII. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro", DNA Research vol. 4:141-150 (1997).
Dunlap, Jay C., et al., "Genetic and Molecular Analysis of Circadian Rhythms", Annual Review Genet., vol. 30:579-601 (1996).
Antoch, Marina P., et al., "Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue", Cell, vol. 89:655-667 (1997).
Hall Jeffrey C., "Tripping along the trail to the molecular mechanisms of biological clocks", Trends Neurosci., vol. 18:230-240 (1995).
Duckworth David Malcolm
Michalovich David
Carlson Karen Cochrane
Han William T.
King William T.
SmithKline Beecham Plc
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