Expression system

Details Expression system Expression system

2007-09-18

2007-09-18

Mondesi, Robert B. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C424S093100

Reexamination Certificate

active

10483150

ABSTRACT:
A recombinant microorganism comprises an asporogenicBacillus subtilisstrain in which a gene encoding a protease enzyme has been downregulated or inactivated. In particular sigma factorspoIIAC is inactivated such that the strain is asporogenic. These strains are particularly useful as expression vehicles for proteins such as protective antigen (PA) ofBacillus anthracis.

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