Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2005-12-01
2009-02-17
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S006000, C800S015000, C800S016000, C435S325000
Reexamination Certificate
active
07491867
ABSTRACT:
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
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Ferguson Stacy E.
Goldsby Richard A.
Ishida Isao
Kuroiwa Yoshimi
Osborne Barbara A.
Clark & Elbing LLP
Crouch Deborah
Kyowa Hakko Kirin Co., Ltd.
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